INT308176

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.19
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, Tnfrsf1a) extracellular region (TNF, Tnfrsf1a) signal transduction (TNF)
nucleus (Tnfrsf1a) plasma membrane (TNF) intracellular (TNF)
TNF (Homo sapiens)
Tnfrsf1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 2 96.58 Very High Very High Very High
Neuropathic pain 57 87.44 High High
Stimulus evoked pain 2 85.68 High High
Pain 10 79.32 Quite High
Lasting pain 5 77.36 Quite High
Thermal hyperalgesia 3 74.08 Quite High
Sciatic nerve 9 62.00 Quite High
Eae 19 61.28 Quite High
Inflammation 14 50.88 Quite High
cytokine 14 38.00 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 3 98.48 Very High Very High Very High
Neuropathic Pain 74 87.44 High High
Hypersensitivity 3 85.68 High High
Pain 15 85.00 Quite High
Non-diabetic Peripheral Neuropathy 4 79.76 Quite High
Cancer 15 75.20 Quite High
Wallerian Degeneration 1 74.48 Quite High
Hyperalgesia 12 74.08 Quite High
Injury 23 63.88 Quite High
INFLAMMATION 19 50.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
enhances the tetrodotoxin-resistant (TTX-R) Na+ current in cultured DRG cells from wild-type but not from TNFR1-knockout mice, and such current is abolished by a p38-MAPK inhibitor; implying that TNF acts via TNFR1 and activates TTX-R Na+ channels via the p38 MAPK system [87].
TNF Regulation (acts) of TNFR1 associated with targeted disruption and tetrodotoxin
1) Confidence 0.05 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2861665 Disease Relevance 1.19 Pain Relevance 0.75

General Comments

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