INT30834

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Context Info
Confidence 0.45
First Reported 1986
Last Reported 2002
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.62
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
brain 2
ovary 2
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 1 99.52 Very High Very High Very High
Dynorphin 4 98.80 Very High Very High Very High
Morphine 3 97.96 Very High Very High Very High
amygdala 6 97.00 Very High Very High Very High
Somatostatin 1 94.36 High High
Neuropeptide 1 93.72 High High
Lasting pain 2 90.84 High High
Serotonin 1 89.28 High High
Endogenous opioid 1 88.96 High High
5HT 3 88.40 High High
Disease Link Frequency Relevance Heat
Pain 3 90.84 High High
Stress 1 88.20 High High
Fibromyalgia 8 86.36 High High
Hypotension 1 81.60 Quite High
Depression 1 46.68 Quite Low
Anxiety Disorder 1 46.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was performed in order to determine (1) if the lesion resulted in a decrease in CRH mRNA, and/or if there was upregulation on the intact side, (2) if a similar imbalance in CRH mRNA was observed in other brain regions and (3) if levels of other neuropeptide mRNAs were affected by the lesion.
Regulation (resulted) of Negative_regulation (decrease) of CRH mRNA in brain associated with neuropeptide
1) Confidence 0.45 Published 2002 Journal Brain Res. Section Abstract Doc Link 12126877 Disease Relevance 0 Pain Relevance 0.50
Inhibition of NPE by morphine, FK 33,824 dynorphin (1-13) and dynorphin (1-10)amide was blocked by naloxone, 1 mg/kg i.v., but the CRF inhibition was not affected.
Neg (not) Regulation (affected) of Negative_regulation (inhibition) of CRF associated with dynorphin, narcan and morphine
2) Confidence 0.27 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2875171 Disease Relevance 0.08 Pain Relevance 0.75
The lowered oestrogen levels could be accounted for both via an inhibitory effect of the CRH on the hypothalamic release of LHRH or via a direct CRH-mediated inhibition of the FSH-stimulated oestrogen production in the ovary.
Regulation (accounted) of Negative_regulation (effect) of CRH in ovary
3) Confidence 0.13 Published 2000 Journal Scand. J. Rheumatol. Suppl. Section Abstract Doc Link 11028824 Disease Relevance 0.53 Pain Relevance 0.55

General Comments

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