INT308354

Context Info Confidence 0.58 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.14 Pain Relevance 0

pigmentation (Snai2) nucleus (Snai2) intracellular (Snai2) embryo development (Snai2) DNA binding (Snai2) cytoplasm (Snai2)

Snai2 (Mus musculus)

Pain Link Frequency Relevance Heat melanocortin 1 receptor 2 5.00 addiction 1 5.00 cytokine 1 5.00 withdrawal 1 5.00 Inflammation 1 5.00 Versed 1 5.00

Disease Link Frequency Relevance Heat Melanoma 27 96.84 Skin Cancer 140 95.80 Disease 8 94.20 Adhesions 3 92.28 Metastasis 14 87.40 Breast Cancer 2 66.16 Sunburn 3 50.00 Cancer 40 38.48 Malignant Neoplastic Disease 3 25.40 Apoptosis 33 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Activation of SLUG expression plays an important role in down-regulation of E-cadherin and tumorigenesis of malignant melanomas.[115] Melanoma cells at initial stages of the disease show reduction or loss of E-cadherin expression, but recovery of its expression is frequently found at advanced phases.[116] Overexpression of E-cadherin leads to defective invasion of melanoma cells.[116]

Gene_expression (expression) of SLUG associated with melanoma, disease and skin cancer

1) Confidence 0.58 Published 2010 Journal Journal of Carcinogenesis Section Body Doc Link PMC2862505 Disease Relevance 1.14 Pain Relevance 0

General Comments

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