INT308354

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Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.14
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Snai2) nucleus (Snai2) intracellular (Snai2)
embryo development (Snai2) DNA binding (Snai2) cytoplasm (Snai2)
Snai2 (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Versed 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 27 96.84 Very High Very High Very High
Skin Cancer 140 95.80 Very High Very High Very High
Disease 8 94.20 High High
Adhesions 3 92.28 High High
Metastasis 14 87.40 High High
Breast Cancer 2 66.16 Quite High
Sunburn 3 50.00 Quite Low
Cancer 40 38.48 Quite Low
Malignant Neoplastic Disease 3 25.40 Quite Low
Apoptosis 33 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of SLUG expression plays an important role in down-regulation of E-cadherin and tumorigenesis of malignant melanomas.[115] Melanoma cells at initial stages of the disease show reduction or loss of E-cadherin expression, but recovery of its expression is frequently found at advanced phases.[116] Overexpression of E-cadherin leads to defective invasion of melanoma cells.[116]


Gene_expression (expression) of SLUG associated with melanoma, disease and skin cancer
1) Confidence 0.58 Published 2010 Journal Journal of Carcinogenesis Section Body Doc Link PMC2862505 Disease Relevance 1.14 Pain Relevance 0

General Comments

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