INT308355

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.42
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Cdkn2a) aging (Cdkn2a) DNA binding (Cdkn2a)
protein complex (Cdkn2a) cytoplasm (Cdkn2a) nucleolus (Cdkn2a)
Cdkn2a (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Versed 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 27 98.48 Very High Very High Very High
Skin Cancer 143 93.20 High High
Cancer 77 87.40 High High
Malignant Neoplastic Disease 8 75.56 Quite High
Sarcoma 17 75.16 Quite High
Carcinoma 4 70.52 Quite High
Metastasis 30 70.00 Quite High
Aging 4 61.60 Quite High
Sunburn 3 50.00 Quite Low
Retinoblastoma 3 35.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studying cells at different phases of transformation, we could show that an early event during transformation was the loss of expression of the CDKN2A locus, followed by inactivation of p53 and overexpression of c-myc.
Negative_regulation (loss) of Gene_expression (expression) of CDKN2A
1) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.58 Pain Relevance 0
Notably, hypermethylation of the CDKN2A promoter region has been shown to lead to loss of p16 expression in 19% of primary and 33% metastatic melanomas.[59] DNA methyltransferase(DNMT) inhibitors namely 5-azacytidine, 5-aza-20-deoxycytidine(decitabine), fazarabine, and dihydro-5-azacytidine have been extensively studied.
Negative_regulation (loss) of Gene_expression (expression) of p16 associated with melanoma
2) Confidence 0.42 Published 2010 Journal Journal of Carcinogenesis Section Body Doc Link PMC2862505 Disease Relevance 0.84 Pain Relevance 0

General Comments

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