INT3084

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Context Info
Confidence 0.42
First Reported 1978
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.20
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (REN) extracellular space (REN) extracellular region (REN)
intracellular (REN) response to stress (REN)
Anatomy Link Frequency
outflow 2
plasma 2
SNS 2
REN (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 17 99.58 Very High Very High Very High
beta blocker 4 97.66 Very High Very High Very High
headache 1 77.76 Quite High
anesthesia 2 75.00 Quite High
backache 1 74.00 Quite High
Angina 1 70.40 Quite High
agonist 1 48.72 Quite Low
Disease Link Frequency Relevance Heat
Hyperkalemia 7 96.40 Very High Very High Very High
Pressure And Volume Under Development 21 93.04 High High
Ganglion Cysts 1 92.48 High High
Disorders Of Creatine Metabolism 1 88.60 High High
Hepatotoxicity 1 82.36 Quite High
Diarrhoea 2 78.56 Quite High
Headache 1 77.76 Quite High
Nasopharyngitis 1 76.96 Quite High
Renal Insufficiency 1 76.84 Quite High
Dizziness 4 75.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clonidine induced a permanent decrease in SNS activity and delayed decrease in renin/aldosterone levels.
Negative_regulation (decrease) of Negative_regulation (decrease) of renin in SNS associated with clonidine
1) Confidence 0.42 Published 2006 Journal Hepatology Section Abstract Doc Link 17006921 Disease Relevance 0.53 Pain Relevance 0.44
Clonidine (30 microgram/kg, iv) lowered mean arterial pressure (MAP) from 124 +/- 8 to 104 +/- 4 mm Hg (P less than 0.01) and reduced plasma renin activity (PRA) to 32 +/- 4 percent of the control value (P less than 0.01) after 60 minutes.
Negative_regulation (lowered) of Negative_regulation (reduced) of renin in plasma associated with clonidine
2) Confidence 0.40 Published 1978 Journal Circ. Res. Section Abstract Doc Link 620441 Disease Relevance 0.24 Pain Relevance 0.34
Although their specific mechanisms of action are incompletely understood, beta blockers are most likely lower blood pressure and provide target organ protection by several different mechanisms, including inhibition of renin-angiotensine system by decreasing renin release by the jugstaglomerular cells of the kidney, central inhibition of sympathetic nervous system outflow and slowing of heart rate with a decrease in cardiac output.
Negative_regulation (inhibition) of Negative_regulation (decreasing) of renin in outflow associated with beta blocker
3) Confidence 0.38 Published 2007 Journal Recent patents on cardiovascular drug discovery Section Abstract Doc Link 18221115 Disease Relevance 0.33 Pain Relevance 0.22
Clonidine-induced angiotensin pressor dose and renin level reduction have been abolished by spironolactone.
Negative_regulation (abolished) of Negative_regulation (reduction) of renin associated with clonidine
4) Confidence 0.38 Published 1978 Journal Int J Clin Pharmacol Biopharm Section Abstract Doc Link 700917 Disease Relevance 0 Pain Relevance 0.45
When this increase occurs during treatment with ACEIs and ARBs, the result is increased levels of PRA but during treatment with aliskiren, the effect of increased renin levels is blocked, so the levels of Ang I and Ang II, as well as PRA, are all reduced.52 The clinical trials do not report any major adverse effects of aliskiren compared with ARBs or ACEs being generally well tolerated by all patients.
Negative_regulation (blocked) of Negative_regulation (effect) of renin
5) Confidence 0.35 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922316 Disease Relevance 1.10 Pain Relevance 0.15
Renal interstitial immunoreactive angiotensin decreased significantly to 124 +/- 37 nmol (P < .01) in response to intrarenal renin inhibition at the end of day 5 of sodium depletion.
Negative_regulation (decreased) of Negative_regulation (inhibition) of renin
6) Confidence 0.26 Published 1995 Journal Hypertension Section Abstract Doc Link 7737709 Disease Relevance 0 Pain Relevance 0.07

General Comments

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