INT308425

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.37
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pde2a, Aip) cytosol (Pde2a, Aip) nucleus (Pde2a, Aip)
plasma membrane (Pde2a, Aip) unfolded protein binding (Aip) Golgi apparatus (Pde2a)
Anatomy Link Frequency
pituitary 1
Pde2a (Rattus norvegicus)
Aip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 3 5.00 Very Low Very Low Very Low
Somatostatin 1 5.00 Very Low Very Low Very Low
amygdala 1 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pituitary Cancer 36 97.80 Very High Very High Very High
Cancer 31 93.44 High High
Multiple Endocrine Neoplasia Type 1 11 92.84 High High
Hypophysis Disease 2 81.28 Quite High
Adrenal Cancer 10 50.56 Quite High
Carney Complex 5 47.40 Quite Low
Multiple Endocrine Neoplasia 2 46.00 Quite Low
Lymphatic System Cancer 5 45.68 Quite Low
Syndrome 5 44.52 Quite Low
Gigantism 2 36.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The fact that AIP interacts with phosphodiesterases type 4A (PDE4A) and type 2A (PDE2A) implicates this gene in the cyclic AMP (cAMP) signaling cascade,12,13 a cellular pathway known to be disrupted in pituitary, but also in thyroid and adrenal tumorigenesis.14,15 Furthermore, AIP is widely expressed, which may argue in favor of a potential involvement of this gene also in non-pituitary tumors.
PDE2A Binding (interacts) of AIP in pituitary associated with pituitary cancer
1) Confidence 0.04 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862671 Disease Relevance 1.37 Pain Relevance 0

General Comments

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