INT308426

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.89
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pde4a, Aip) cytoplasm (Pde4a, Aip) unfolded protein binding (Aip)
cytosol (Aip) signal transduction (Pde4a) nucleolus (Aip)
Anatomy Link Frequency
leukocyte 1
Pde4a (Mus musculus)
Aip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 3 5.00 Very Low Very Low Very Low
Somatostatin 1 5.00 Very Low Very Low Very Low
amygdala 1 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 5 86.72 High High
Adrenal Cancer 10 84.92 Quite High
Acromegaly 8 80.80 Quite High
Cancer 31 80.32 Quite High
Multiple Endocrine Neoplasia Type 1 11 78.60 Quite High
Pituitary Cancer 36 75.40 Quite High
Hodgkin's Disease 8 5.00 Very Low Very Low Very Low
Carney Complex 5 5.00 Very Low Very Low Very Low
Syndrome 5 5.00 Very Low Very Low Very Low
Multiple Endocrine Neoplasia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The functional inactivating mutation c.241C>T (R81X), which blocks the AIP protein from interacting with phosphodiesterase 4A (PDE4A), was identified in the heterozygous state in the leukocyte DNA of both patients.
phosphodiesterase 4A Binding (interacting) of AIP in leukocyte
1) Confidence 0.02 Published 2010 Journal Clinics (Sao Paulo) Section Abstract Doc Link PMC2862671 Disease Relevance 0.89 Pain Relevance 0

General Comments

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