INT308430

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.83
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRKAR1A) signal transduction (PRKAR1A) small molecule metabolic process (PRKAR1A)
protein complex (PRKAR1A) transmembrane transport (PRKAR1A)
Anatomy Link Frequency
pituitary 1
PRKAR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
amygdala 1 84.28 Quite High
imagery 3 5.00 Very Low Very Low Very Low
Somatostatin 1 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pituitary Cancer 36 90.96 High High
Lymphatic System Cancer 5 83.08 Quite High
Hodgkin's Disease 8 79.80 Quite High
Acromegaly 8 66.96 Quite High
Adrenal Cancer 10 64.60 Quite High
Cancer 31 45.76 Quite Low
Multiple Endocrine Neoplasia Type 1 11 5.00 Very Low Very Low Very Low
Carney Complex 5 5.00 Very Low Very Low Very Low
Syndrome 5 5.00 Very Low Very Low Very Low
Multiple Endocrine Neoplasia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutant AIP cannot interact with cAMP-specific PDE4A and therefore is likely to disrupt the cAMP signaling pathway.12,27,28 This pathway has been previously implicated in both pituitary and non-pituitary tumorigenesis through defects in the PRKAR1A,29 GNAS1,30 PDE11A31 and PDE8B32 genes.
Negative_regulation (defects) of PRKAR1A in pituitary
1) Confidence 0.11 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862671 Disease Relevance 0.83 Pain Relevance 0.04

General Comments

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