INT308432

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.10
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE4A, Aip) plasma membrane (PDE4A, Aip) nucleus (PDE4A, Aip)
cytoplasm (PDE4A, Aip) unfolded protein binding (Aip) signal transduction (PDE4A)
Anatomy Link Frequency
pituitary 2
leukocyte 1
PDE4A (Homo sapiens)
Aip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 3 93.00 High High
imagery 9 5.00 Very Low Very Low Very Low
Somatostatin 3 5.00 Very Low Very Low Very Low
Dismenorea 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pituitary Cancer 108 98.32 Very High Very High Very High
Cancer 93 93.44 High High
Multiple Endocrine Neoplasia Type 1 33 92.84 High High
Lymphatic System Cancer 15 91.80 High High
Hodgkin's Disease 24 88.52 High High
Adrenal Cancer 30 84.92 Quite High
Hypophysis Disease 6 81.28 Quite High
Acromegaly 24 80.80 Quite High
Carney Complex 15 47.40 Quite Low
Multiple Endocrine Neoplasia 6 46.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutant AIP cannot interact with cAMP-specific PDE4A and therefore is likely to disrupt the cAMP signaling pathway.12,27,28 This pathway has been previously implicated in both pituitary and non-pituitary tumorigenesis through defects in the PRKAR1A,29 GNAS1,30 PDE11A31 and PDE8B32 genes.
PDE4A Spec (likely) Binding (interact) of AIP in pituitary
1) Confidence 0.05 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862671 Disease Relevance 0.89 Pain Relevance 0.05
The functional inactivating mutation c.241C>T (R81X), which blocks the AIP protein from interacting with phosphodiesterase 4A (PDE4A), was identified in the heterozygous state in the leukocyte DNA of both patients.
PDE4A Binding (interacting) of AIP in leukocyte
2) Confidence 0.05 Published 2010 Journal Clinics (Sao Paulo) Section Abstract Doc Link PMC2862671 Disease Relevance 0.89 Pain Relevance 0
The fact that AIP interacts with phosphodiesterases type 4A (PDE4A) and type 2A (PDE2A) implicates this gene in the cyclic AMP (cAMP) signaling cascade,12,13 a cellular pathway known to be disrupted in pituitary, but also in thyroid and adrenal tumorigenesis.14,15 Furthermore, AIP is widely expressed, which may argue in favor of a potential involvement of this gene also in non-pituitary tumors.
PDE4A Binding (interacts) of AIP in pituitary associated with pituitary cancer
3) Confidence 0.04 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862671 Disease Relevance 1.32 Pain Relevance 0

General Comments

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