INT308473

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Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 12
Disease Relevance 13.26
Pain Relevance 7.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptafr) plasma membrane (Ptafr) nucleus (Ptafr)
signal transducer activity (Ptafr)
Anatomy Link Frequency
neuronal 3
macrophages 3
nerve 2
neurons 1
peripheral nerve 1
Ptafr (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 204 99.72 Very High Very High Very High
dorsal root ganglion 1128 99.68 Very High Very High Very High
Peripheral nerve injury 156 99.44 Very High Very High Very High
Pain 72 98.58 Very High Very High Very High
Brush evoked pain 576 97.68 Very High Very High Very High
Neuropathic pain 144 97.36 Very High Very High Very High
Spinal cord 84 87.76 High High
Spinal nerve ligature 12 84.52 Quite High
tetrodotoxin 12 77.08 Quite High
Action potential 12 74.88 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1140 99.68 Very High Very High Very High
Nervous System Injury 696 99.58 Very High Very High Very High
Pain 96 98.58 Very High Very High Very High
Neuropathic Pain 792 97.68 Very High Very High Very High
Targeted Disruption 12 92.48 High High
Injury 48 87.52 High High
Nociception 48 67.12 Quite High
Neurodegenerative Disease 12 59.60 Quite High
Cv Unclassified Under Development 12 56.72 Quite High
Demyelinating Disease 24 55.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, the present study provided the first evidence that the activation of the PAFR may be a key event in the development and maintenance of tactile allodynia and production of proinflammatory cytokines such as TNF?
Positive_regulation (activation) of PAFR associated with brush evoked pain and cytokine
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.28 Pain Relevance 0.89
Upregulation of the PAFR in the DRG after peripheral nerve injury
Positive_regulation (Upregulation) of PAFR in peripheral nerve associated with dorsal root ganglion, nervous system injury and peripheral nerve injury
2) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.48 Pain Relevance 0.66
Alternatively, infiltration of macrophages expressing PAFR in the DRG after nerve injury might result in the upregulation of PAFR mRNA, because PAFR is expressed in macrophages [35] and is involved in macrophage chemotaxis [48] and the number of macrophages in the DRG is increased following peripheral nerve injury [49].
Positive_regulation (upregulation) of PAFR in macrophage associated with dorsal root ganglion, nervous system injury and peripheral nerve injury
3) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.46 Pain Relevance 0.87
Activation of PAFR may lead to production and release of proinflammatory cytokines.
Positive_regulation (Activation) of PAFR associated with cytokine
4) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.08 Pain Relevance 0.76
It is conceivable that peripheral nerve injury causes the transcriptional upregulation of PAFR in macrophages in the DRG.
Positive_regulation (upregulation) of PAFR in macrophages associated with dorsal root ganglion, nervous system injury and peripheral nerve injury
5) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.52 Pain Relevance 0.90
Non-neuronal and neuronal cells with a higher violet intensity than the sections hybridized with sense probe were considered positively labeled for PAFR mRNA.
Positive_regulation (labeled) of PAFR in neuronal
6) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 0.11 Pain Relevance 0.03
PAF may be released from DRG neurons and then activates PAFR expressed in macrophages.
Positive_regulation (activates) of PAFR in neurons associated with dorsal root ganglion
7) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.07 Pain Relevance 0.74
In in situ hybridization analysis, we found that the intensity of PAFR mRNA signals and the number of cells with strong signal of PAFR mRNA were increased in the ipsilateral DRG 7 days after nerve injury (Fig. 6C) compared with the contralateral DRG (Fig. 6B).
Positive_regulation (intensity) of PAFR in nerve associated with dorsal root ganglion and nervous system injury
8) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.22 Pain Relevance 0.48
This is consistent with the notion that macrophages are one of the major sources of these proinflammatory cytokines and regulate pain signaling [49], [50], [51], [52], although it remains unknown whether PAFR activation leads to upregulation of proinflammatory cytokine expression in macrophages.
Spec (whether) Positive_regulation (activation) of PAFR in macrophages associated with pain and cytokine
9) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.37 Pain Relevance 0.99
It remains unclear whether the expression of these cytokines results from PAFR activation in non-neuronal cells in the DRG.
Spec (whether) Positive_regulation (activation) of PAFR in neuronal associated with dorsal root ganglion and cytokine
10) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.39 Pain Relevance 1.13
In in situ hybridization analysis, we found that the intensity of PAFR mRNA signals and the number of cells with strong signal of PAFR mRNA were increased in the ipsilateral DRG 7 days after nerve injury (Fig. 6C) compared with the contralateral DRG (Fig. 6B).
Positive_regulation (increased) of PAFR in nerve associated with dorsal root ganglion and nervous system injury
11) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.16 Pain Relevance 0.45
Non-neuronal and neuronal cells with a higher violet intensity than the sections hybridized with sense probe were considered positively labeled for PAFR mRNA.
Positive_regulation (labeled) of PAFR in neuronal
12) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 0.11 Pain Relevance 0.03

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