INT308474

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Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 7.33
Pain Relevance 3.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptafr) plasma membrane (Ptafr) nucleus (Ptafr)
signal transducer activity (Ptafr)
Anatomy Link Frequency
nerve 4
neuronal 2
neurons 2
Ptafr (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 470 100.00 Very High Very High Very High
Peripheral nerve injury 65 99.80 Very High Very High Very High
Brush evoked pain 240 98.84 Very High Very High Very High
Spinal cord 35 94.28 High High
Neuropathic pain 60 88.20 High High
Opioid 10 76.56 Quite High
cytokine 85 75.00 Quite High
allodynia 25 75.00 Quite High
antagonist 45 74.12 Quite High
Lasting pain 10 71.48 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 475 100.00 Very High Very High Very High
Nervous System Injury 290 99.80 Very High Very High Very High
Neuropathic Pain 330 98.84 Very High Very High Very High
Injury 20 98.28 Very High Very High Very High
Cancer 10 81.44 Quite High
Necrosis 10 80.96 Quite High
Pain 40 71.48 Quite High
Hypersensitivity 15 70.24 Quite High
Hyperalgesia 15 52.40 Quite High
INFLAMMATION 10 24.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, our in situ hybridization experiments revealed that following peripheral nerve injury a marked increase in PAFR mRNA expression was seen mainly in non-neuronal cells positive to Iba1.
Positive_regulation (increase) of Transcription (expression) of PAFR in neuronal associated with nervous system injury and peripheral nerve injury
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.63 Pain Relevance 0.95
The upregulation of PAFR mRNA expression on day 14 was not suppressed by CV-3988 administered for 14 days (116% of the ipsilateral DRG of vehicle-treated rats).
Positive_regulation (upregulation) of Transcription (expression) of PAFR associated with dorsal root ganglion
2) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.37 Pain Relevance 0.53
We found that the expression of PAFR mRNA in the ipsilateral DRG was markedly increased after nerve injury (Fig. 6A).
Positive_regulation (increased) of Transcription (expression) of PAFR in nerve associated with dorsal root ganglion and nervous system injury
3) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.37 Pain Relevance 0.55
The expression of PAFR mRNA was increased in the DRG ipsilateral to nerve injury, which was seen mainly in macrophages.
Positive_regulation (increased) of Transcription (expression) of PAFR in nerve associated with dorsal root ganglion and nervous system injury
4) Confidence 0.39 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2862737 Disease Relevance 1.88 Pain Relevance 1.22
The expression of PAFR mRNA was increased in the cells (arrowheads) surrounding DRG neurons (indicated as ‘N’) in the ipsilateral DRG (Fig. 6C).
Positive_regulation (increased) of Transcription (expression) of PAFR in neurons associated with dorsal root ganglion
5) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.09 Pain Relevance 0.42

General Comments

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