INT308477

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.51
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 4.30
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptafr) plasma membrane (Ptafr) nucleus (Ptafr)
signal transducer activity (Ptafr)
Anatomy Link Frequency
macrophages 4
nerve 2
Ptafr (Mus musculus)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 39 99.98 Very High Very High Very High
dorsal root ganglion 282 99.48 Very High Very High Very High
Spinal cord 21 88.84 High High
Brush evoked pain 144 86.44 High High
antagonist 27 68.68 Quite High
cytokine 51 65.52 Quite High
Pain 18 63.68 Quite High
Neuropathic pain 36 62.76 Quite High
allodynia 15 50.00 Quite Low
Thermal hyperalgesia 6 46.96 Quite Low
Disease Link Frequency Relevance Heat
Nervous System Injury 174 99.98 Very High Very High Very High
Ganglion Cysts 285 99.48 Very High Very High Very High
Neuropathic Pain 198 86.44 High High
Injury 12 80.92 Quite High
Pain 24 63.68 Quite High
Hyperalgesia 9 46.96 Quite Low
INFLAMMATION 6 18.72 Low Low
Nociception 12 16.88 Low Low
Hypersensitivity 9 5.00 Very Low Very Low Very Low
Demyelinating Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is conceivable that peripheral nerve injury causes the transcriptional upregulation of PAFR in macrophages in the DRG.
Positive_regulation (causes) of Positive_regulation (upregulation) of PAFR in macrophages associated with dorsal root ganglion, nervous system injury and peripheral nerve injury
1) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.54 Pain Relevance 0.91
In in situ hybridization analysis, we found that the intensity of PAFR mRNA signals and the number of cells with strong signal of PAFR mRNA were increased in the ipsilateral DRG 7 days after nerve injury (Fig. 6C) compared with the contralateral DRG (Fig. 6B).
Positive_regulation (increased) of Positive_regulation (intensity) of PAFR in nerve associated with dorsal root ganglion and nervous system injury
2) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.24 Pain Relevance 0.49
Alternatively, infiltration of macrophages expressing PAFR in the DRG after nerve injury might result in the upregulation of PAFR mRNA, because PAFR is expressed in macrophages [35] and is involved in macrophage chemotaxis [48] and the number of macrophages in the DRG is increased following peripheral nerve injury [49].
Spec (might) Positive_regulation (result) of Positive_regulation (upregulation) of PAFR in macrophage associated with dorsal root ganglion, nervous system injury and peripheral nerve injury
3) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.52 Pain Relevance 0.90

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox