INT308479

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Context Info
Confidence 0.60
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 10.05
Pain Relevance 4.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptafr) plasma membrane (Ptafr) nucleus (Ptafr)
signal transducer activity (Ptafr)
Anatomy Link Frequency
nerve 2
spinal nerve 1
neuronal 1
neurons 1
Ptafr (Mus musculus)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 91 99.56 Very High Very High Very High
dorsal root ganglion 658 99.36 Very High Very High Very High
Brush evoked pain 336 98.84 Very High Very High Very High
Neuropathic pain 84 93.88 High High
Spinal cord 49 93.80 High High
Opioid 14 76.56 Quite High
cytokine 119 75.00 Quite High
allodynia 35 75.00 Quite High
antagonist 63 73.64 Quite High
Lasting pain 14 71.48 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 406 99.76 Very High Very High Very High
Ganglion Cysts 665 99.36 Very High Very High Very High
Neuropathic Pain 462 98.84 Very High Very High Very High
Injury 28 98.66 Very High Very High Very High
Cancer 14 79.92 Quite High
Necrosis 14 79.44 Quite High
Pain 56 71.48 Quite High
Hypersensitivity 21 68.72 Quite High
Hyperalgesia 21 51.92 Quite High
INFLAMMATION 14 23.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, our in situ hybridization experiments revealed that following peripheral nerve injury a marked increase in PAFR mRNA expression was seen mainly in non-neuronal cells positive to Iba1.
Transcription (expression) of PAFR in neuronal associated with nervous system injury and peripheral nerve injury
1) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.62 Pain Relevance 0.94
The upregulation of PAFR mRNA expression on day 14 was not suppressed by CV-3988 administered for 14 days (116% of the ipsilateral DRG of vehicle-treated rats).
Transcription (expression) of PAFR associated with dorsal root ganglion
2) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.36 Pain Relevance 0.52
A significant increase was observed from day 3 after injury (p<0.01 compared with the value of the contralateral hindpaw) and PAFR mRNA levels peaked on day 14 (day 7: p<0.01, day 14: p<0.001 compared with the value of contralateral hindpaw and day 7: p<0.01, day 14: p<0.001 compared with that of naïve group) (Fig. 6A).
Transcription (levels) of PAFR associated with injury
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.33 Pain Relevance 0.50
We found that the expression of PAFR mRNA in the ipsilateral DRG was markedly increased after nerve injury (Fig. 6A).
Transcription (expression) of PAFR in nerve associated with dorsal root ganglion and nervous system injury
4) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.35 Pain Relevance 0.54
The expression of PAFR mRNA was increased in the cells (arrowheads) surrounding DRG neurons (indicated as ‘N’) in the ipsilateral DRG (Fig. 6C).
Transcription (expression) of PAFR in neurons associated with dorsal root ganglion
5) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.08 Pain Relevance 0.42
The expression of PAFR mRNA was increased in the DRG ipsilateral to nerve injury, which was seen mainly in macrophages.
Transcription (expression) of PAFR in nerve associated with dorsal root ganglion and nervous system injury
6) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2862737 Disease Relevance 1.87 Pain Relevance 1.22
We next examined the level of PAFR mRNA in total RNA extracts from the L5 DRG ipsilateral and contralateral to an injury to the L5 spinal nerve.
Spec (examined) Transcription (level) of PAFR in spinal nerve associated with dorsal root ganglion and injury
7) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.43 Pain Relevance 0.62

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