INT30851

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Context Info
Confidence 0.67
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.64
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (NRG1) extracellular space (NRG1) extracellular region (NRG1)
plasma membrane (NRG1) nucleus (NRG1) embryo development (NRG1)
Anatomy Link Frequency
nasal 1
NRG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
algil 3 97.12 Very High Very High Very High
abdominal pain 1 94.64 High High
Pain management 1 93.60 High High
Dopamine 1 92.96 High High
pain labor 2 89.28 High High
Inflammation 14 84.96 Quite High
interneuron 1 69.04 Quite High
Pain 8 68.88 Quite High
cytokine 6 68.56 Quite High
GABAergic 2 64.56 Quite High
Disease Link Frequency Relevance Heat
Fistula 12 100.00 Very High Very High Very High
Glaucoma 65 99.68 Very High Very High Very High
Schizophrenia 9 99.40 Very High Very High Very High
Cognitive Disorder 8 98.86 Very High Very High Very High
Choroideremia 166 97.28 Very High Very High Very High
Vomiting 2 96.08 Very High Very High Very High
Cancer 110 95.92 Very High Very High Very High
Abdominal Pain 1 94.64 High High
Pain 7 93.16 High High
Muscular Dystrophy 2 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The average time interval between gastric bypass surgery and GGF presentation was 81 months.
Gene_expression (presentation) of GGF associated with fistula
1) Confidence 0.67 Published 2010 Journal Obes Surg Section Abstract Doc Link 20440578 Disease Relevance 1.25 Pain Relevance 0.09
Interestingly, expression levels of genes encoding secreted proteins from different functional groups including CFI, CC2, NRG1, MMP7, WNT5A, RSOPO2, CSF3R, DPP4, IL1 were deregulated altered in CHM cells compared to the control.
Gene_expression (expression) of NRG1 associated with choroideremia
2) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.77 Pain Relevance 0.06
Metropolitan families (ARIA+ ?
Gene_expression (families) of ARIA
3) Confidence 0.06 Published 2007 Journal BMC Health Serv Res Section Abstract Doc Link PMC1821320 Disease Relevance 0.15 Pain Relevance 0
Furthermore, altered expression of other genes such as nuclear orphan transcription factor Nur-related receptor 1 (Nurr1) (Xing et al. 2006) or Neuregulin 1 is altered in schizophrenia (Harrison and Law 2006; Addington et al. 2007).
Gene_expression (expression) of Neuregulin 1 associated with schizophrenia
4) Confidence 0.06 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2871377 Disease Relevance 0.71 Pain Relevance 0.14
Most probably it will not be until one of the various ARIA developments (e.g. nasal insulin) makes it into a financially attractive product (sufficient return on investment) that more money will flow again in this area of research.
Gene_expression (developments) of ARIA in nasal
5) Confidence 0.06 Published 2010 Journal Int J Clin Pract Suppl Section Abstract Doc Link 20377662 Disease Relevance 0.06 Pain Relevance 0.12
Reciprocal translocations seem to be common; for example, one translocation causes abnormal expression of the NRG1 gene which encodes ligands of the epidermal growth factor receptor (EGFR) family [16].
Gene_expression (expression) of NRG1 gene
6) Confidence 0.02 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397525 Disease Relevance 0.32 Pain Relevance 0
Our analyses also indicate that glaucoma leads to lower expression levels for a large number of genes, including various neurofilaments, synucleins, and neuregulin 1.
Gene_expression (expression) of neuregulin associated with glaucoma
7) Confidence 0.01 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965571 Disease Relevance 0.65 Pain Relevance 0.04
Cognitive groups included: systematic desensitization (SYS DENS); sensory description (SEN DESC); sensory transformation (ST); modeling (M); and relaxation (R); combined groups: SYS DENS, SEN DESC, and ST; SEN DESC, ST, and R; SEN DESC, R, ST, and Demerol.
Gene_expression (groups) of sensory description associated with cognitive disorder and algil
8) Confidence 0.00 Published 1986 Journal Nurs Res Section Abstract Doc Link 2875439 Disease Relevance 0.73 Pain Relevance 0.66

General Comments

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