INT308528

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.23
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CCR3) extracellular space (CCR3) cell adhesion (CCR3)
plasma membrane (CCR3) signal transducer activity (CCR3)
Anatomy Link Frequency
sputum 1
CCR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 11 100.00 Very High Very High Very High
Inflammation 39 99.82 Very High Very High Very High
cytokine 33 55.92 Quite High
Central nervous system 21 32.40 Quite Low
agonist 14 5.00 Very Low Very Low Very Low
corticosteroid 12 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
cocaine 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 36 99.82 Very High Very High Very High
Hypersensitivity 56 99.56 Very High Very High Very High
Asthma 100 97.52 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 110 85.04 High High
Targeted Disruption 2 84.40 Quite High
Adhesions 15 78.88 Quite High
Viral Meningitis 18 66.64 Quite High
Infection 34 65.28 Quite High
Eosinophilia 2 61.60 Quite High
Dementia 17 37.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It contains two modified phosphorothioate anti-sense oligonucleotides designed to inhibit allergic inflammation by down-regulating human CCR3 and the common beta-chain of IL-3, IL-5 and GM CSF.
Regulation (regulating) of CCR3 associated with inflammation and hypersensitivity
1) Confidence 0.31 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.70 Pain Relevance 0.05
The allergen-induced levels of beta-chain mRNA and CCR3 mRNA in sputum-derived cells were inhibited by TPIASM8, but no significant effects on cell surface protein expression of CCR3 and the beta-chain were found.
Neg (no) Regulation (effects) of CCR3 in sputum
2) Confidence 0.19 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.75 Pain Relevance 0.04
resulted in an up-regulation of the chemokine receptors CCR3 and CCR5 in HBMECs which in turn may have enhanced the toxic interaction with the viral envelope protein [88].
Regulation (regulation) of chemokine receptors CCR3 associated with chemokine
3) Confidence 0.00 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 0.78 Pain Relevance 0.11

General Comments

This test has worked.

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