INT30857

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Context Info
Confidence 0.48
First Reported 1984
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 2.27
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OXTR) signal transducer activity (OXTR)
Anatomy Link Frequency
myometrium 1
uterine muscle 1
OXTR (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 6 100.00 Very High Very High Very High
opiate 4 100.00 Very High Very High Very High
Opioid 1 100.00 Very High Very High Very High
Inflammation 10 99.64 Very High Very High Very High
Dismenorea 11 99.08 Very High Very High Very High
agonist 4 91.60 High High
chemokine 1 90.40 High High
bradykinin 1 89.92 High High
Morphine 9 84.16 Quite High
antagonist 2 83.36 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 11 99.64 Very High Very High Very High
Dysmenorrhea 11 99.08 Very High Very High Very High
Hemorrhage 11 93.04 High High
Reprotox - General 3 2 83.52 Quite High
Disease 7 80.40 Quite High
Cv General 3 Under Development 33 75.52 Quite High
Premature Birth 1 59.84 Quite High
Pressure Volume 2 Under Development 25 54.76 Quite High
Fetal Distress 1 54.00 Quite High
Anxiety Disorder 20 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most probable is the interaction between oxytocin and prostaglandines which leads to the onset of labour; the influence of the fetus on this procedure is discussed.
oxytocin Binding (interaction) of
1) Confidence 0.48 Published 1986 Journal Wien Med Wochenschr Section Abstract Doc Link 2875565 Disease Relevance 0.36 Pain Relevance 0.24
The stimulation of the uterine muscle during labour results from an interaction of oxytocin and prostaglandin (PG) F2 alpha.
oxytocin Binding (interaction) of in uterine muscle
2) Confidence 0.48 Published 1984 Journal Br J Obstet Gynaecol Section Abstract Doc Link 6091729 Disease Relevance 0.06 Pain Relevance 0.06
The factors which control oxytocin receptor formation are therefore important; this may be one of the processes where the steroids play a crucial role.
oxytocin Binding (formation) of
3) Confidence 0.37 Published 1984 Journal Br J Obstet Gynaecol Section Abstract Doc Link 6091729 Disease Relevance 0.10 Pain Relevance 0.10
Further developments led to two modified oxytocin molecules with higher receptor affinity for human myometrium, both of which lacked agonism in humans.
oxytocin Binding (led) of in myometrium
4) Confidence 0.37 Published 2003 Journal BJOG Section Abstract Doc Link 12763125 Disease Relevance 0.25 Pain Relevance 0.33
The study of the interaction between exogenously administered opiates and oxytocin secretion may give insight into the activity of any opiate-mediated regulatory mechanism of oxytocin secretion in the fetus.
oxytocin Binding (interaction) of associated with opiate
5) Confidence 0.36 Published 1998 Journal Clin. Sci. Section Abstract Doc Link 9662490 Disease Relevance 0 Pain Relevance 0.80
Oxytocin radioimmunoassay
Oxytocin Binding (radioimmunoassay) of
6) Confidence 0.31 Published 2006 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC1621060 Disease Relevance 0 Pain Relevance 0.12
Real-time detection of interactions between the human oxytocin receptor and G protein-coupled receptor kinase-2.
oxytocin receptor Binding (interactions) of
7) Confidence 0.21 Published 2004 Journal Mol. Endocrinol. Section Title Doc Link 14976224 Disease Relevance 0.10 Pain Relevance 0.18
Other peptide activated GPCRs implicated in inflammation, like those that bind angiotensin II, N-formyl peptides, galanin, neuropeptide Y, opioids and oxytocin, are only briefly discussed because there is either less direct association with inflammation or few/no nonpeptidic antiinflammatory ligands known.
oxytocin Binding (bind) of associated with inflammation, neuropeptide and opioid
8) Confidence 0.09 Published 2005 Journal Curr. Med. Chem. Section Abstract Doc Link 16378503 Disease Relevance 1.03 Pain Relevance 0.53
Management of labour 3rd stage was routine active management with oxytocin 10 units or syntometrine one ampoule soon after the birth.
oxytocin Binding (management) of
9) Confidence 0.08 Published 2004 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC514549 Disease Relevance 0.38 Pain Relevance 0.07
The interactions between oxytocin and other mediators involved such as connexin-43 and NO cannot be excluded (14).
oxytocin Binding (interactions) of
10) Confidence 0.02 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1475867 Disease Relevance 0 Pain Relevance 0

General Comments

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