INT3086

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Context Info
Confidence 0.47
First Reported 1978
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 7.10
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pf4) extracellular region (Pf4) protein complex assembly (Pf4)
molecular_function (Pf4) protein complex (Pf4)
Anatomy Link Frequency
platelet 10
blood 2
Pf4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bioavailability 6 94.56 High High
ischemia 6 91.04 High High
Serotonin 5 84.68 Quite High
Angina 9 76.36 Quite High
cva 322 59.92 Quite High
Catecholamine 2 55.52 Quite High
antagonist 26 26.08 Quite Low
headache 5 22.44 Low Low
palliative 6 5.00 Very Low Very Low Very Low
aspirin 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heparin-induced Thrombocytopenia 489 99.70 Very High Very High Very High
Coronary Artery Disease 15 98.40 Very High Very High Very High
Stress 1 97.84 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 94.28 High High
Thrombocytopenia 89 91.48 High High
Thrombosis 169 86.88 High High
Frailty 2 82.40 Quite High
Myocardial Infarction 31 78.20 Quite High
Coronary Vasospasm 2 77.16 Quite High
Cv General 3 Under Development 36 76.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following incubation at 4 degrees C for 24 hr, bound PF-4 was precipitated with 2.2M ammonium sulfate.
PF-4 Binding (bound) of
1) Confidence 0.47 Published 1978 Journal J. Lab. Clin. Med. Section Abstract Doc Link 621432 Disease Relevance 0.31 Pain Relevance 0.12
We used a recently described radioimmunoassay for the platelet-secreted protein platelet factor 4 (PF4) to study 162 patients with documented coronary artery disease.
PF4 Binding (radioimmunoassay) of in platelet associated with coronary artery disease
2) Confidence 0.34 Published 1981 Journal Circulation Section Abstract Doc Link 6973419 Disease Relevance 0.63 Pain Relevance 0.06
Platelet activation was measured by radioimmunoassay of plasma platelet factor 4 (PF4), beta-thromboglobulin (BTG), and thromboxane B2 (TXB2) in blood samples withdrawn through catheters, and fibrin formation was assessed by determination of fibrinopeptide A (FPA) levels.
PF4 Binding (radioimmunoassay) of in blood
3) Confidence 0.16 Published 1984 Journal Circulation Section Abstract Doc Link 6237807 Disease Relevance 0.23 Pain Relevance 0.08
Platelet activation was measured by radioimmunoassay of plasma platelet factor 4 (PF4), beta-thromboglobulin (BTG), and thromboxane B2 (TXB2) in blood samples withdrawn through catheters, and fibrin formation was assessed by determination of fibrinopeptide A (FPA) levels.
plasma platelet factor 4 Binding (radioimmunoassay) of in blood
4) Confidence 0.14 Published 1984 Journal Circulation Section Abstract Doc Link 6237807 Disease Relevance 0.23 Pain Relevance 0.08
Because of opposite charges, heparin and other glycosaminoglycans bind to the PF4 molecules, exposing neoepitopes that act as immunogens leading to antibody production.
PF4 Binding (bind) of
5) Confidence 0.08 Published 2005 Journal Thromb J Section Body Doc Link PMC1262784 Disease Relevance 0.40 Pain Relevance 0
Finally, heparin binds to platelet factor IV (PF4) which reduces its anticoagulant effect, and can lead to the development of heparin-induced thrombocytopenia (HIT).
PF4 Binding (binds) of in platelet associated with heparin-induced thrombocytopenia
6) Confidence 0.08 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2496976 Disease Relevance 0.26 Pain Relevance 0.09
In fact, patients who develop HIT produce an IgG antibody against the heparin-PF4 complex, which binds to the complex on platelet surface through the Fab region [20].
PF4 Binding (binds) of in platelet associated with heparin-induced thrombocytopenia
7) Confidence 0.07 Published 2005 Journal Thromb J Section Body Doc Link PMC1262784 Disease Relevance 0.45 Pain Relevance 0
In patients diagnosed for HIT, antibodies directed against the complex of heparin and platelet factor 4 (PF4) are generated.
platelet factor 4 Binding (complex) of in platelet associated with heparin-induced thrombocytopenia
8) Confidence 0.07 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721302 Disease Relevance 0.80 Pain Relevance 0.08
In patients diagnosed for HIT, antibodies directed against the complex of heparin and platelet factor 4 (PF4) are generated.
PF4 Binding (complex) of in platelet associated with heparin-induced thrombocytopenia
9) Confidence 0.07 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721302 Disease Relevance 0.80 Pain Relevance 0.08
Finally, heparin binds to platelet factor IV (PF4) which reduces its anticoagulant effect, and can lead to the development of heparin-induced thrombocytopenia (HIT).
platelet factor IV Binding (binds) of in platelet associated with heparin-induced thrombocytopenia
10) Confidence 0.07 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2496976 Disease Relevance 0.26 Pain Relevance 0.09
When platelets are activated, PF4 is released into the circulation and some of it binds to the platelet surface.
PF4 Binding (binds) of in platelet
11) Confidence 0.06 Published 2005 Journal Thromb J Section Body Doc Link PMC1262784 Disease Relevance 0.45 Pain Relevance 0
The immunoassays utilize immunoenzymatic tests (enzyme-linked immunesorbent assay, ELISA) to detect the HIT antibody that binds to the PF4/heparin complex.
PF4 Binding (binds) of associated with heparin-induced thrombocytopenia
12) Confidence 0.06 Published 2005 Journal Thromb J Section Body Doc Link PMC1262784 Disease Relevance 0.70 Pain Relevance 0.04
The principal antigen is a complex of heparin and platelet factor 4 (PF4).
PF4 Binding (complex) of in platelet
13) Confidence 0.06 Published 2005 Journal Thromb J Section Body Doc Link PMC1262784 Disease Relevance 0.50 Pain Relevance 0
In vivo platelet activation was assessed by radioimmunoassay of platelet factor 4, beta-thrombo-globulin and thromboxane B2.
platelet factor 4 Binding (radioimmunoassay) of in platelet
14) Confidence 0.03 Published 1983 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 6339591 Disease Relevance 0.51 Pain Relevance 0.11
It does not bind to other plasma proteins, blood cells, or platelet factor 4, making the risk of heparin-induced thrombocytopenia very low (Warkentin et al 2005).
platelet factor 4 Neg (not) Binding (bind) of in platelet associated with heparin-induced thrombocytopenia
15) Confidence 0.01 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684509 Disease Relevance 0.56 Pain Relevance 0.03

General Comments

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