INT308656

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.80
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pik3r1, Nos3) signal transduction (Pik3r1, Nos3) nucleus (Pik3r1, Nos3)
plasma membrane (Pik3r1, Nos3) mitochondrion (Nos3) Golgi apparatus (Nos3)
Pik3r1 (Mus musculus)
Nos3 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 36 89.52 High High
Bioavailability 4 78.24 Quite High
Inflammation 36 75.00 Quite High
cytokine 26 23.88 Low Low
chemokine 4 23.48 Low Low
Central nervous system 28 5.00 Very Low Very Low Very Low
Hippocampus 20 5.00 Very Low Very Low Very Low
cerebral cortex 6 5.00 Very Low Very Low Very Low
diabetic neuropathy 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 40 86.72 High High
Atherosclerosis 4 79.44 Quite High
INFLAMMATION 40 75.00 Quite High
Congenital Anomalies 12 65.64 Quite High
Adhesions 12 57.56 Quite High
Chronic Disease 2 57.52 Quite High
Diabetes Mellitus 100 55.36 Quite High
Necrosis 4 54.12 Quite High
Cancer 2 53.76 Quite High
Dementia 30 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FFAs inhibit the PI3K/AKT pathway, which, aside from controlling insulin-stimulated glucose uptake, is also needed to stimulate endothelial NOS (e-NOS).
PI3K Positive_regulation (stimulate) of e-NOS
1) Confidence 0.02 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.90 Pain Relevance 0.25
FFAs inhibit the PI3K/AKT pathway, which, aside from controlling insulin-stimulated glucose uptake, is also needed to stimulate endothelial NOS (e-NOS).
PI3K Positive_regulation (stimulate) of endothelial NOS
2) Confidence 0.02 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.90 Pain Relevance 0.25

General Comments

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