INT308658

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.15
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Apoa2, Apoe) lipid binding (Apoa2, Apoe) extracellular space (Apoa2, Apoe)
extracellular region (Apoa2, Apoe) aging (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
neurons 1
Apoa2 (Mus musculus)
Apoe (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 14 55.00 Quite High
Hippocampus 10 45.12 Quite Low
Thalamus 1 42.88 Quite Low
Kinase C 18 5.00 Very Low Very Low Very Low
Inflammation 18 5.00 Very Low Very Low Very Low
cytokine 13 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
diabetic neuropathy 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 8 100.00 Very High Very High Very High
Dementia 15 50.00 Quite Low
Disease 100 26.60 Quite Low
Heart Disease 3 26.32 Quite Low
Increased Venous Pressure Under Development 20 25.72 Quite Low
Congenital Anomalies 6 22.56 Low Low
Diabetes Mellitus 50 5.00 Very Low Very Low Very Low
INFLAMMATION 20 5.00 Very Low Very Low Very Low
Cardiovascular Disease 19 5.00 Very Low Very Low Very Low
Vascular Dementia 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After cholesterol is synthesised in astrocytes, it is released through ABCA1 and packaged into lipoprotein particles resembling HDL, which in turn are then taken up into neurons through the recognition of ApoE by a variety of lipoprotein receptors such as LDLR, LRP and the ApoE receptor.
HDL Binding (recognition) of ApoE in neurons associated with disorder of lipid metabolism
1) Confidence 0.17 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.15 Pain Relevance 0.03

General Comments

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