INT308666

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.69
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lrp1) endosome (Lrp1) plasma membrane (Lrp1)
nucleus (Lrp1) cytoplasm (Lrp1)
Anatomy Link Frequency
glial cells 1
Neurons 1
Lrp1 (Mus musculus)
Chol1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 28 93.68 High High
Kinase C 36 5.00 Very Low Very Low Very Low
Inflammation 36 5.00 Very Low Very Low Very Low
cytokine 26 5.00 Very Low Very Low Very Low
Hippocampus 20 5.00 Very Low Very Low Very Low
cerebral cortex 6 5.00 Very Low Very Low Very Low
diabetic neuropathy 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 16 88.80 High High
Disease 200 65.28 Quite High
Heart Disease 6 65.00 Quite High
Increased Venous Pressure Under Development 40 64.40 Quite High
Congenital Anomalies 12 61.24 Quite High
Dementia 30 50.00 Quite Low
Diabetes Mellitus 100 5.00 Very Low Very Low Very Low
INFLAMMATION 40 5.00 Very Low Very Low Very Low
Cardiovascular Disease 38 5.00 Very Low Very Low Very Low
Vascular Dementia 34 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neurons and glial cells contain LRP receptors, which are large endocytic membrane receptors that can bind and internalise the ApoE-cholesterol phospholipid complex and then fuse with lysosomes.
LRP Binding (bind) of cholesterol in glial cells
1) Confidence 0.10 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.34 Pain Relevance 0.05
Neurons and glial cells contain LRP receptors, which are large endocytic membrane receptors that can bind and internalise the ApoE-cholesterol phospholipid complex and then fuse with lysosomes.
LRP Binding (bind) of cholesterol in Neurons
2) Confidence 0.03 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.34 Pain Relevance 0.05

General Comments

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