INT308667

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.14
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Chrm1, App) Golgi apparatus (App) extracellular matrix organization (App)
DNA binding (App) cytoplasm (App) signal transducer activity (Chrm1)
Anatomy Link Frequency
hippocampus 6
Chrm1 (Mus musculus)
App (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 20 97.56 Very High Very High Very High
Neurotransmitter 6 91.40 High High
Kinase C 36 5.00 Very Low Very Low Very Low
Inflammation 36 5.00 Very Low Very Low Very Low
Central nervous system 28 5.00 Very Low Very Low Very Low
cytokine 26 5.00 Very Low Very Low Very Low
cerebral cortex 6 5.00 Very Low Very Low Very Low
diabetic neuropathy 6 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 200 98.92 Very High Very High Very High
Proteostasis Deficiencies 2 80.04 Quite High
Cognitive Disorder 16 69.16 Quite High
Dementia 30 50.00 Quite Low
Shock 4 33.60 Quite Low
Neurodegenerative Disease 18 31.24 Quite Low
Apoptosis 12 18.00 Low Low
Alzheimer's Dementia 8 8.84 Low Low
Diabetes Mellitus 100 5.00 Very Low Very Low Very Low
INFLAMMATION 40 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the binding of ACh to its muscarinergic m1 and m3 receptors can then stimulate the formation of soluble APP (sAPP). sAPP in turn can then modulate synaptic plasticity in the hippocampus and promotes dendritic outgrowth [32].
m1 Binding (binding) of in hippocampus Positive_regulation (stimulate) of APP Binding (formation) of in hippocampus associated with hippocampus
1) Confidence 0.04 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.57 Pain Relevance 0.16
In addition, the binding of ACh to its muscarinergic m1 and m3 receptors can then stimulate the formation of soluble APP (sAPP). sAPP in turn can then modulate synaptic plasticity in the hippocampus and promotes dendritic outgrowth [32].
m1 Binding (binding) of in hippocampus Positive_regulation (stimulate) of sAPP Binding (formation) of in hippocampus associated with hippocampus
2) Confidence 0.04 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.57 Pain Relevance 0.16

General Comments

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