INT308668

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.61
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Akt1, Nos3) signal transduction (Akt1, Nos3) nucleus (Akt1, Nos3)
plasma membrane (Akt1, Nos3) mitochondrion (Nos3) transport (Akt1)
Akt1 (Mus musculus)
Nos3 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 38 89.52 High High
Bioavailability 4 78.04 Quite High
Inflammation 42 74.80 Quite High
cytokine 28 73.96 Quite High
agonist 46 73.44 Quite High
chemokine 4 23.28 Low Low
Central nervous system 28 5.00 Very Low Very Low Very Low
Hippocampus 20 5.00 Very Low Very Low Very Low
cerebral cortex 6 5.00 Very Low Very Low Very Low
diabetic neuropathy 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 6 99.46 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 6 95.24 Very High Very High Very High
Increased Venous Pressure Under Development 50 86.52 High High
Stress 30 85.60 High High
Death 18 80.72 Quite High
Atherosclerosis 4 79.24 Quite High
INFLAMMATION 50 74.80 Quite High
Metabolic Disorder 18 67.44 Quite High
Congenital Anomalies 12 65.44 Quite High
Injury 2 63.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, hypoxia-activated AMPK stimulates Akt that phosphorylates and activates endothelial nitrogen oxide synthase (eNOS) (Serine 1177) (Figure 2) [53, 54].
Akt Positive_regulation (activates) of eNOS associated with hypoxia
1) Confidence 0.05 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 1.41 Pain Relevance 0.07
In addition, hypoxia-activated AMPK stimulates Akt that phosphorylates and activates endothelial nitrogen oxide synthase (eNOS) (Serine 1177) (Figure 2) [53, 54].
Akt Positive_regulation (activates) of endothelial nitrogen oxide synthase associated with hypoxia
2) Confidence 0.05 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 1.41 Pain Relevance 0.07
FFAs inhibit the PI3K/AKT pathway, which, aside from controlling insulin-stimulated glucose uptake, is also needed to stimulate endothelial NOS (e-NOS).
AKT Positive_regulation (stimulate) of e-NOS
3) Confidence 0.03 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.90 Pain Relevance 0.25
FFAs inhibit the PI3K/AKT pathway, which, aside from controlling insulin-stimulated glucose uptake, is also needed to stimulate endothelial NOS (e-NOS).
AKT Positive_regulation (stimulate) of endothelial NOS
4) Confidence 0.03 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.90 Pain Relevance 0.25

General Comments

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