INT308701

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.53
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (AQP4) helicase activity (DDX41) transmembrane transport (AQP4)
cytoplasm (AQP4) RNA binding (DDX41) nucleolus (DDX41)
Anatomy Link Frequency
M-1 1
AQP4 (Homo sapiens)
DDX41 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 42 94.12 High High
Neuritis 33 93.00 High High
Demyelination 21 55.16 Quite High
Central nervous system 12 5.00 Very Low Very Low Very Low
Sicca syndrome 9 5.00 Very Low Very Low Very Low
headache 6 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Sciatica 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 282 100.00 Very High Very High Very High
Disease 42 97.72 Very High Very High Very High
Neurological Disease 27 94.44 High High
Demyelinating Disease 78 94.12 High High
Optic Neuritis 30 93.00 High High
Systemic Lupus Erythematosus 45 87.00 High High
Recurrence 18 77.88 Quite High
Syndrome 42 55.16 Quite High
Transverse Myelitis 27 5.00 Very Low Very Low Very Low
Headache 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggest M-23 AQP4 as initial and major target antigen for antibody binding in definite and high risk NMO patients, whereas Abs to M-1 AQP4 are predominantly developed with increasing disease duration and severity.
AQP4 Binding (binding) of Abs in M-1 associated with neuromyelitis optica and disease
1) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 1.13 Pain Relevance 0.13
In comparison to AQP4-IgG, AQP4-IgM Abs are not a reliable biomarker, although they were elevated in definite and high risk NMO patients.
AQP4-IgG Neg (not) Binding (biomarker) of Abs associated with neuromyelitis optica
2) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 1.17 Pain Relevance 0.14
NMO-Ig Abs resulted in different staining patterns when binding to full length AQP4 in contrast to the M-23 AQP4 isoform.
AQP4 Binding (binding) of Abs associated with neuromyelitis optica
3) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 1.22 Pain Relevance 0.06

General Comments

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