INT308715

Context Info Confidence 0.08 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 2.12 Pain Relevance 0.12

nucleolus (DDX41) RNA binding (DDX41) nucleus (DDX41) helicase activity (DDX41)

Anatomy Link Frequency M-1 1 DDX41 (Homo sapiens)

Pain Link Frequency Relevance Heat Demyelination 7 83.64 Multiple sclerosis 14 69.08 Neuritis 11 43.92 Central nervous system 4 5.00 Sicca syndrome 3 5.00 headache 2 5.00 Spinal cord 1 5.00 Analgesic 1 5.00 Inflammation 1 5.00 Sciatica 1 5.00

Disease Link Frequency Relevance Heat Neuromyelitis Optica 94 100.00 Disease 14 97.88 Recurrence 6 96.64 Systemic Lupus Erythematosus 15 84.00 Syndrome 14 83.76 Demyelinating Disease 26 83.44 Neurological Disease 9 76.08 Transverse Myelitis 9 45.88 Optic Neuritis 10 43.92 Headache 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The conformational epitopes of M-23 AQP4 are the primary targets of NMO-IgG Abs, whereas M-1 AQP4 Abs are developed with increasing disease duration and number of relapses.

Regulation (targets) of Abs in M-1 associated with neuromyelitis optica, disease and recurrence

1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2864757 Disease Relevance 2.12 Pain Relevance 0.12

General Comments

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