INT308715

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 2.12
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (DDX41) RNA binding (DDX41) nucleus (DDX41)
helicase activity (DDX41)
Anatomy Link Frequency
M-1 1
DDX41 (Homo sapiens)
Pain Link Frequency Relevance Heat
Demyelination 7 83.64 Quite High
Multiple sclerosis 14 69.08 Quite High
Neuritis 11 43.92 Quite Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Sicca syndrome 3 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Sciatica 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 94 100.00 Very High Very High Very High
Disease 14 97.88 Very High Very High Very High
Recurrence 6 96.64 Very High Very High Very High
Systemic Lupus Erythematosus 15 84.00 Quite High
Syndrome 14 83.76 Quite High
Demyelinating Disease 26 83.44 Quite High
Neurological Disease 9 76.08 Quite High
Transverse Myelitis 9 45.88 Quite Low
Optic Neuritis 10 43.92 Quite Low
Headache 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The conformational epitopes of M-23 AQP4 are the primary targets of NMO-IgG Abs, whereas M-1 AQP4 Abs are developed with increasing disease duration and number of relapses.


Regulation (targets) of Abs in M-1 associated with neuromyelitis optica, disease and recurrence
1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2864757 Disease Relevance 2.12 Pain Relevance 0.12

General Comments

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