INT308793

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 0.51
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Pld2) plasma membrane (Pld2) nucleus (Pld2)
Anatomy Link Frequency
neuronal 1
CPA 1
Pld2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 80 97.32 Very High Very High Very High
agonist 15 92.56 High High
Potency 3 63.60 Quite High
Inflammation 124 58.00 Quite High
chemokine 44 48.00 Quite Low
alcohol 2 46.88 Quite Low
antagonist 15 35.60 Quite Low
Inflammatory response 43 21.28 Low Low
fibrosis 9 5.00 Very Low Very Low Very Low
Neuropathic pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fever 9 73.68 Quite High
Targeted Disruption 18 73.12 Quite High
Cancer 36 66.24 Quite High
Metastasis 10 65.68 Quite High
Apoptosis 24 59.28 Quite High
INFLAMMATION 167 58.00 Quite High
Pox Virus Infection 10 50.64 Quite High
Adhesions 26 46.16 Quite Low
Cv General 2 Under Development 6 41.92 Quite Low
Disease 43 19.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies reported that PLD1 and PLD2 mRNAs [13], [14], [15], [30], as well as PLD3 mRNA [23], [24], are highly expressed in various brain regions and in many non-neuronal tissues.
Gene_expression (expressed) of PLD2 in neuronal
1) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978679 Disease Relevance 0 Pain Relevance 0
In the C-terminal region, PLD family members (with the exception of PLD6) possess two PDE domains, PLD-PDE1 and PLD-PDE2, which contain HKD – HKD1 and HKD2 – respectively (Fig. 1B).
Gene_expression (possess) of PLD-PDE2
2) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978679 Disease Relevance 0 Pain Relevance 0
PLD comprises two major isoforms, PLD1 and PLD2, expressed in a wide range of almost all the mammalian tissues [18], [26].
Gene_expression (expressed) of PLD2
3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864766 Disease Relevance 0.19 Pain Relevance 0.08
Among the PXPH-PLDs, expression of PLD1 mRNA was low and gradually decreased after birth, whereas PLD2 expression was greater and peaked at P7 before decreasing thereafter (Fig. 2A).
Gene_expression (expression) of PLD2
4) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978679 Disease Relevance 0.05 Pain Relevance 0
For enzymatic activity analysis, the mouse PLD2 expression vector pcGN-mPLD2 [14], which was kindly provided by Dr.
Gene_expression (expression) of PLD2
5) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978679 Disease Relevance 0 Pain Relevance 0
For enzymatic activity analysis, the mouse PLD2 expression vector pcGN-mPLD2 [14], which was kindly provided by Dr.
Gene_expression (expression) of mPLD2
6) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978679 Disease Relevance 0 Pain Relevance 0
In mammalian cells, CPA is generated intracellularly by PLD2 and acts as a second messenger which inhibits PPAR?
Gene_expression (generated) of PLD2 in CPA
7) Confidence 0.22 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.13 Pain Relevance 0.12
Since both the PLD isoforms are expressed in BALB/c mice [35], we determined the isoform-specific knockdown of PLD1 by evaluating the expression of PLD2 as well, following the above-mentioned siRNA intravenous administration.
Gene_expression (expression) of PLD2
8) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864766 Disease Relevance 0.07 Pain Relevance 0.04
The level of mPLD2 expression remained unaffected subsequent to siRNA treatment specific for PLD1 (Fig. 1B), indicating the efficiency and specificity of the isoform-specific siRNA knockdown of PLD1 in vivo.


Gene_expression (expression) of mPLD2
9) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864766 Disease Relevance 0.07 Pain Relevance 0.04

General Comments

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