INT308846

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.06
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map1lc3a) cytoskeleton (Map1lc3a) cytoplasm (Map1lc3a)
Map1lc3a (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 2 7.32 Low Low
Hippocampus 3 6.40 Low Low
cerebral cortex 1 5.88 Low Low
Clonidine 7 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
antinociception 1 5.00 Very Low Very Low Very Low
nMDA receptor 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Antinociceptive 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 50 58.64 Quite High
Toxicity 3 50.00 Quite Low
Death 7 23.40 Low Low
Weight Loss 4 22.60 Low Low
Tremor 11 22.08 Low Low
Targeted Disruption 19 19.00 Low Low
Hypertension 4 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Sleep Disorders 3 5.00 Very Low Very Low Very Low
Neurologic Gait Disorders 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This also allowed us to demonstrate that this increase in LC3-II levels results from an increase in synthesis rather than a decrease in degradation of autophagosomes, as increased levels were also seen in the presence of bafilomycin A1, an autophagy inhibitor that blocks autophagosome-lysosome fusion and therefore LC3-II degradation (27) (Fig. 1E and F).
Negative_regulation (blocks) of Protein_catabolism (degradation) of LC3-II
1) Confidence 0.41 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.06 Pain Relevance 0

General Comments

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