INT308847

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 2.11
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Eif4ebp1) protein complex (Eif4ebp1) cytoplasm (Eif4ebp1)
Anatomy Link Frequency
PP2A 2
Eif4ebp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 51 94.00 High High
ischemia 180 87.96 High High
alcohol 5 74.76 Quite High
Clonidine 14 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
addiction 5 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 157 94.28 High High
Disease 99 91.68 High High
Cv Unclassified Under Development 175 87.96 High High
Cv General 4 Under Development 5 77.44 Quite High
Glioma 5 76.20 Quite High
Alzheimer's Dementia 5 75.88 Quite High
Toxicity 12 75.12 Quite High
Brain Disease 5 73.72 Quite High
Hypoxia 31 69.64 Quite High
Repression 5 65.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, it has been reported that ROS inhibit protein phosphatase 2A (PP2A) (41, 42), phosphatase activity that has been implicated in regulation of 4E-BP1 phosphorylation (7, 30, 43). 4E-BP1 phosphorylation at Ser64, but not Thr69, is induced by ROS (44).
Regulation (regulation) of Phosphorylation (phosphorylation) of 4E-BP1 in PP2A
1) Confidence 0.27 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.21 Pain Relevance 0.04
This study also addressed the role of 4E-BP1 phosphorylation in the activity of eIF4E.
Regulation (role) of Phosphorylation (phosphorylation) of 4E-BP1
2) Confidence 0.27 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.56 Pain Relevance 0.08
Long term reperfusion (R3d) did not induce any significant effect on 4E-BP1 phosphorylation with respect to the SHC3d control (Fig. 1; supplemental Figs.
Regulation (effect) of Phosphorylation (phosphorylation) of 4E-BP1
3) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.28 Pain Relevance 0.19
Changes in 4E-BP1 phosphorylation after IR were according to those found for Akt and mammalian target of rapamycin (mTOR) kinases.
Regulation (Changes) of Phosphorylation (phosphorylation) of 4E-BP1
4) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2966049 Disease Relevance 0.56 Pain Relevance 0.07
These data help to elucidate the physiological role of 4E-BP1 phosphorylation in controlling protein synthesis.



Regulation (role) of Phosphorylation (phosphorylation) of 4E-BP1
5) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2966049 Disease Relevance 0.22 Pain Relevance 0.04
Unlike rapamycin, which has previously been identified as a possible therapeutic due to its upregulation of autophagy, rilmenidine had no effect on phosphorylation of p70 S6 kinase (Fig. 1G), S6 protein (Fig. 1H) or 4E-BP1 (Fig. 1I), all downstream substrates of mTOR kinase activity.


Neg (no) Regulation (effect) of Phosphorylation (phosphorylation) of 4E-BP1
6) Confidence 0.07 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.16 Pain Relevance 0
In order to examine potential mechanisms by which antioxidants may influence autophagy, we examined their effect on the mTOR pathway, a classical negative regulator of autophagy, by looking for changes in the phosphorylation status of an mTOR kinase substrate 4E binding protein 1 (4E-BP1) and a protein dependent on mTOR substrate kinase activity, ribosomal protein S6 (S6).
Regulation (dependent) of Phosphorylation (phosphorylation) of 4E-BP1
7) Confidence 0.00 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2916709 Disease Relevance 0.13 Pain Relevance 0

General Comments

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