INT308848

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.48
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gopc) Golgi apparatus (Gopc) plasma membrane (Gopc)
cytoplasm (Gopc)
Gopc (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 12 50.00 Quite Low
tolerance 6 29.28 Quite Low
Clonidine 21 5.00 Very Low Very Low Very Low
Hippocampus 9 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
medulla 6 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 150 92.08 High High
Toxicity 16 50.00 Quite Low
Coronary Heart Disease 4 50.00 Quite Low
Tremor 33 37.04 Quite Low
Impaired Glucose Tolerance 10 29.28 Quite Low
Death 21 7.48 Low Low
Weight Loss 12 6.68 Low Low
Targeted Disruption 62 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 13 5.00 Very Low Very Low Very Low
Hypertension 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unlike rapamycin, which has previously been identified as a possible therapeutic due to its upregulation of autophagy, rilmenidine had no effect on phosphorylation of p70 S6 kinase (Fig. 1G), S6 protein (Fig. 1H) or 4E-BP1 (Fig. 1I), all downstream substrates of mTOR kinase activity.


Neg (no) Regulation (effect) of Phosphorylation (phosphorylation) of Fig
1) Confidence 0.28 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.16 Pain Relevance 0
Unlike rapamycin, which has previously been identified as a possible therapeutic due to its upregulation of autophagy, rilmenidine had no effect on phosphorylation of p70 S6 kinase (Fig. 1G), S6 protein (Fig. 1H) or 4E-BP1 (Fig. 1I), all downstream substrates of mTOR kinase activity.


Neg (no) Regulation (effect) of Phosphorylation (phosphorylation) of Fig
2) Confidence 0.28 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.16 Pain Relevance 0
Unlike rapamycin, which has previously been identified as a possible therapeutic due to its upregulation of autophagy, rilmenidine had no effect on phosphorylation of p70 S6 kinase (Fig. 1G), S6 protein (Fig. 1H) or 4E-BP1 (Fig. 1I), all downstream substrates of mTOR kinase activity.


Neg (no) Regulation (effect) of Phosphorylation (phosphorylation) of Fig
3) Confidence 0.28 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.16 Pain Relevance 0
Last but not the least, ADH transgene itself did not affect LKB1 phosphorylation (Fig. 8).


Neg (not) Regulation (affect) of Phosphorylation (phosphorylation) of Fig
4) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0

General Comments

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