INT30885

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Context Info
Confidence 0.36
First Reported 1986
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 6.99
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Nefl) locomotion (Nefl)
Anatomy Link Frequency
neuronal 1
lateral 1
Brain 1
motor neurons 1
Neurites 1
Nefl (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 28 97.68 Very High Very High Very High
Neuropeptide 2 95.96 Very High Very High Very High
Neuritis 4 90.80 High High
dorsal root ganglion 76 78.24 Quite High
Sciatic nerve 124 76.04 Quite High
Nerve growth factor 10 75.00 Quite High
Enkephalin 1 71.32 Quite High
Somatostatin 1 68.96 Quite High
Arachnoiditis 4 68.72 Quite High
Spinal cord 40 6.12 Low Low
Disease Link Frequency Relevance Heat
Brain Injury 116 99.00 Very High Very High Very High
Neurodegenerative Disease 16 98.80 Very High Very High Very High
Injury 128 98.72 Very High Very High Very High
Congenital Anomalies 4 97.96 Very High Very High Very High
Infection 80 97.88 Very High Very High Very High
Motor Neuron Diseases 4 97.44 Very High Very High Very High
Death 4 97.12 Very High Very High Very High
Disease 80 96.20 Very High Very High Very High
Parkinson's Disease 4 96.04 Very High Very High Very High
Convulsion 4 95.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Excess accumulation of NF-L was also observed in several neurodegenerative diseases, e.g., amyotrophic lateral sclerosis, AD, Lewy bodies in Parkinson's disease, Charcot-Marie-Tooth disease, and giant axonal neuropathy [12].
Positive_regulation (accumulation) of NF-L in lateral associated with parkinson's disease, charcot marie tooth disease, giant axonal neuropathy, mouth disease, disease, neurodegenerative disease and motor neuron diseases
1) Confidence 0.36 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2442079 Disease Relevance 2.01 Pain Relevance 0.08
It was found that excess accumulation of NF-L has a detrimental effect on nerve cells resulting from NF-L inclusions in axons mechanically blocking the transportation of particles through axons, which eventually leads to neuronal death and to abnormalities in and degeneration of motor neurons [63].
Positive_regulation (accumulation) of NF-L in motor neurons associated with congenital anomalies and death
2) Confidence 0.26 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2442079 Disease Relevance 2.10 Pain Relevance 0.09
1 and S100B (Fig. 5C, D), glial proteins, GFAP and NF-L (Fig. 6C, D), and enzyme, tTG (Fig. 7C, D), coincided with their protein levels, with significantly elevated levels of mRNA seen at 1 and 4 wpi.
Positive_regulation (elevated) of NF-L
3) Confidence 0.24 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2442079 Disease Relevance 0.83 Pain Relevance 0.12
The degree of augmentation in Ndel1 levels also correlated with higher levels of GAP-43, a neuronal marker for axonal regeneration, and with stabilization of NF-L, a marker for advanced regeneration and maturation (Fig. 2C).
Positive_regulation (stabilization) of NF-L in neuronal
4) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.22 Pain Relevance 0.07
The stabilization of NF-L and increased GAP-43 did not correlate with the formation of the truncated fragments of Vimentin (Fig. 2C, graph).
Positive_regulation (stabilization) of NF-L
5) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.22 Pain Relevance 0.06
Brain injury-associated biomarkers of TGF-beta1, S100B, GFAP, NF-L, tTG, AbetaPP, and tau were concomitantly enhanced and the UPS was impaired during acute brain injury caused by Toxocara canis in mice

Background

Positive_regulation (enhanced) of NF-L in Brain associated with brain injury
6) Confidence 0.11 Published 2008 Journal BMC Infect Dis Section Title Doc Link PMC2442079 Disease Relevance 1.07 Pain Relevance 0
Neurites of some cells from each of the above populations were strongly immunoreactive for alpha neurofilament protein, and for NAPA73 neurofilament-associated protein.
Positive_regulation (immunoreactive) of alpha neurofilament protein in Neurites
7) Confidence 0.09 Published 1986 Journal J. Neurosci. Res. Section Abstract Doc Link 2876107 Disease Relevance 0 Pain Relevance 0.35
During axon regeneration, the developmental pattern of IFs resumes: Vimentin is re-upregulated and expression of mature IFs such as NF-L and NF-H decreases [11]–[15], [17], [27], [32].
Positive_regulation (upregulated) of NF-L
8) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.32 Pain Relevance 0.07
The stabilization of NF-L and increased GAP-43 did not correlate with the formation of the truncated fragments of Vimentin (Fig. 2C, graph).
Positive_regulation (increased) of NF-L
9) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.22 Pain Relevance 0.06

General Comments

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