INT308851

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.35
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nisch) endosome (Nisch) plasma membrane (Nisch)
cytoplasm (Nisch)
Anatomy Link Frequency
hippocampus 4
cerebral cortex 1
striatum 1
Nisch (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 3 97.04 Very High Very High Very High
Hippocampus 9 96.36 Very High Very High Very High
Clonidine 21 95.40 Very High Very High Very High
medulla 6 95.28 Very High Very High Very High
Antinociceptive 3 94.16 High High
antinociception 3 88.12 High High
agonist 6 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 150 99.68 Very High Very High Very High
Sleep Disorders 9 92.84 High High
Heart Rate Under Development 3 90.96 High High
Targeted Disruption 57 67.44 Quite High
Hypertension 12 62.72 Quite High
Tremor 33 61.04 Quite High
Weight Loss 12 60.32 Quite High
Death 21 58.24 Quite High
Machado-joseph Disease 3 51.80 Quite High
Toxicity 9 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The imidazoline I1 receptor is expressed in regions affected by the HD mutation in both the rodent and human, including the striatum, cerebral cortex, hippocampus, ventrolateral medulla and hypothalamus (22–25).
Regulation (affected) of Gene_expression (expressed) of imidazoline I1 receptor in hippocampus associated with medulla, hippocampus, disease and cerebral cortex
1) Confidence 0.04 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.78 Pain Relevance 0.62
The imidazoline I1 receptor is expressed in regions affected by the HD mutation in both the rodent and human, including the striatum, cerebral cortex, hippocampus, ventrolateral medulla and hypothalamus (22–25).
Regulation (affected) of in striatum Gene_expression (expressed) of imidazoline I1 receptor in hippocampus associated with medulla, hippocampus, disease and cerebral cortex
2) Confidence 0.01 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.78 Pain Relevance 0.62
The imidazoline I1 receptor is expressed in regions affected by the HD mutation in both the rodent and human, including the striatum, cerebral cortex, hippocampus, ventrolateral medulla and hypothalamus (22–25).
Regulation (affected) of in cerebral cortex Gene_expression (expressed) of imidazoline I1 receptor in hippocampus associated with medulla, hippocampus, disease and cerebral cortex
3) Confidence 0.01 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.78 Pain Relevance 0.62

General Comments

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