INT30887

Context Info Confidence 0.59 First Reported 1982 Last Reported 2011 Negated 0 Speculated 0 Reported most in Abstract Documents 56 Total Number 56 Disease Relevance 32.96 Pain Relevance 20.86

signal transduction (Ngf) extracellular space (Ngf) extracellular region (Ngf)

Anatomy Link Frequency neurons 6 bladder 2 neuronal 2 nerve 2 Brain 1 Ngf (Mus musculus)

Pain Link Frequency Relevance Heat Nerve growth factor 437 100.00 Hyperalgesia 30 99.92 Dismenorea 3 99.92 qutenza 109 99.84 dorsal root ganglion 251 99.60 nociceptor 45 99.44 diabetic neuropathy 13 99.40 ischemia 27 99.38 bDMF 20 99.36 Central nervous system 74 99.08

Disease Link Frequency Relevance Heat Hyperalgesia 38 99.92 Leishmaniasis 14 99.92 Dysmenorrhea 3 99.92 Apoptosis 1636 99.86 Death 724 99.78 Neuropathy 11 99.76 Ganglion Cysts 327 99.60 Schistosomiasis 2 99.58 Targeted Disruption 124 99.54 Diabetic Neuropathy 47 99.40

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Ovariectomy caused a significant decrease in NGF protein content in the uterus, and short term treatment of ovariectomized mice with estrogen and/or progesterone increased uterine NGF mRNA and restored NGF protein to concentrations similar to intact control mice.

Negative_regulation (decrease) of NGF protein in uterus associated with nerve growth factor

1) Confidence 0.59 Published 2002 Journal Neuroscience Section Abstract Doc Link 11882380 Disease Relevance 0.13 Pain Relevance 0.49

NGF down-regulation is known to occur during terminal myogenic differentiation.

Negative_regulation (down-regulation) of NGF associated with nerve growth factor

2) Confidence 0.59 Published 2003 Journal J. Mol. Endocrinol. Section Abstract Doc Link 12580757 Disease Relevance 0.19 Pain Relevance 0.46

We found that treatment of mice with the estrogen antagonist ICI 182,780 had no effect on bladder NGF content but decreased bladder NGF messenger RNA.

Negative_regulation (decreased) of NGF in bladder associated with nerve growth factor and antagonist

3) Confidence 0.58 Published 2001 Journal Urology Section Abstract Doc Link 11378049 Disease Relevance 0.60 Pain Relevance 0.94

After capsaicin inhalation, there was an increase in NGF in the patient group (mean increase after provocation: 11.1 pg/mL; 95% CI, 3.1–19.1; p < 0.01) but not among control subjects, who displayed a decrease in NGF (mean decrease after provocation: 3.2 pg/mL; 95% CI, ?

Negative_regulation (decrease) of NGF associated with nerve growth factor and qutenza

4) Confidence 0.58 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257644 Disease Relevance 0.08 Pain Relevance 0.96

We also found that cardiac NGF downregulation is a cause of diabetic neuropathy, and that NGF supplementation rescues silent myocardial ischemia in DM.

Negative_regulation (downregulation) of NGF associated with coronary artery disease, nerve growth factor, diabetes mellitus, ischemia and diabetic neuropathy

5) Confidence 0.58 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 18673222 Disease Relevance 1.18 Pain Relevance 0.41

We also show that the downregulation of cardiac NGF is a cause of diabetic neuropathy and that NGF supplementation prevents silent myocardial ischemia in diabetes mellitus.

Negative_regulation (downregulation) of NGF associated with coronary artery disease, nerve growth factor, diabetes mellitus, ischemia and diabetic neuropathy

6) Confidence 0.57 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19270423 Disease Relevance 0.98 Pain Relevance 0.41

However, it has been shown that chronic NGF deprivation (by exogenous administration of an anti-NGF polyclonal antibody or autoimmunization to NGF) results in a modest hypoalgesia, where animals are less sensitive to some thermal and algogenic stimuli [38].

Negative_regulation (deprivation) of NGF associated with algogenic, nerve growth factor and hypoalgesia

7) Confidence 0.51 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 0.69 Pain Relevance 0.89

In fact, the observed reduction of NGF, MCP-1, and IL-6 mRNAs in the DMSO-treated bladders could suggest the inhibitory effect of DMSO on abnormal activation of sensory neurons, urothelial cells, mast cells, and detrusor muscle cells.

Negative_regulation (reduction) of NGF in urothelial cells associated with nerve growth factor and overactive bladder

8) Confidence 0.51 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2989383 Disease Relevance 0.90 Pain Relevance 0.29

Behavioral effects of early deprivation of nerve growth factor: some similarities with familial dysautonomia.

Negative_regulation (deprivation) of nerve growth factor in nerve associated with familial dysautonomia, nerve growth factor and nociceptor

9) Confidence 0.48 Published 1982 Journal Brain Res. Section Title Doc Link 7059836 Disease Relevance 0.26 Pain Relevance 0.20

We conclude that thymulin can modulate the hyperalgesia induced by CL by decreasing the levels of the proinflammatory factors IL-1beta and NGF.

Negative_regulation (decreasing) of NGF associated with leishmaniasis, hyperalgesia and nerve growth factor

10) Confidence 0.43 Published 2002 Journal Brain Behav. Immun. Section Abstract Doc Link 12096890 Disease Relevance 1.04 Pain Relevance 0.77

Mice with CL showed sustained increase in the levels of IL-1beta and NGF which were reversed by thymulin (1 microg).

Negative_regulation (reversed) of NGF associated with leishmaniasis and nerve growth factor

11) Confidence 0.43 Published 2002 Journal Brain Behav. Immun. Section Abstract Doc Link 12096890 Disease Relevance 0.91 Pain Relevance 0.79

Mice lacking a functional NGF gene (ngf-/- mice) have less than one third of the normal complement of sensory neurons, few sympathetic postganglionic neurons and die shortly after birth.

Negative_regulation (lacking) of NGF gene in neurons

12) Confidence 0.43 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15010204 Disease Relevance 0.30 Pain Relevance 0.10

To examine this hypothesis we used two lines of transgenic mice that contained a supernormal number of either NGF- or GDNF-dependent neurons (referred to as NGF-OE and GDNF-OE mice, respectively).

Negative_regulation (number) of NGF in neurons associated with targeted disruption and nerve growth factor

13) Confidence 0.43 Published 2003 Journal Pain Section Abstract Doc Link 14659533 Disease Relevance 1.05 Pain Relevance 1.02

After capsaicin inhalation, there was an increase in NGF in the patient group (mean increase after provocation: 11.1 pg/mL; 95% CI, 3.1–19.1; p < 0.01) but not among control subjects, who displayed a decrease in NGF (mean decrease after provocation: 3.2 pg/mL; 95% CI, ?

Negative_regulation (decrease) of NGF associated with nerve growth factor and qutenza

14) Confidence 0.43 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257644 Disease Relevance 0.08 Pain Relevance 0.96

Four hours after intravesical instillation of NGF, the threshold of the hind paws to mechanical stimulation was significantly decreased, and this effect was reversed by prior treatment with NGF antiserum.

Negative_regulation (decreased) of NGF associated with nerve growth factor

15) Confidence 0.43 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16203088 Disease Relevance 0.34 Pain Relevance 0.75

This effect is at least partially mediated by NGF, and the bladder may be the source of NGF in this process.

Negative_regulation (source) of NGF in bladder associated with nerve growth factor

16) Confidence 0.43 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16203088 Disease Relevance 0.21 Pain Relevance 0.66

Anti-NGF inhibition of process formation among ELI cells could be reversed with exogenous NGF.

Negative_regulation (reversed) of NGF associated with nerve growth factor

17) Confidence 0.43 Published 1986 Journal J. Neurosci. Res. Section Abstract Doc Link 2876107 Disease Relevance 0 Pain Relevance 0.52

Rescue of NGF-deficient mice I: transgenic expression of NGF in skin rescues mice lacking endogenous NGF.

Negative_regulation (lacking) of NGF in skin associated with targeted disruption and nociceptor

18) Confidence 0.43 Published 2004 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 15010204 Disease Relevance 0.42 Pain Relevance 0.61

Inhibition of the retrograde transport of NGF by capsaicin preceded substance P depletion.

Negative_regulation (Inhibition) of NGF associated with qutenza, nerve growth factor and substance p

19) Confidence 0.43 Published 1982 Journal Brain Res. Section Abstract Doc Link 6182949 Disease Relevance 0 Pain Relevance 1.20

Treatment of sensitized and aerosol challenged BALB/c mice with blocking anti-NGF antibodies inhibited allergen-induced early-phase reaction and suppressed airway inflammation.

Negative_regulation (blocking) of NGF associated with inflammation and nerve growth factor

20) Confidence 0.43 Published 2002 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 12231491 Disease Relevance 0.96 Pain Relevance 0.61

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