INT308875

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.90
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry12) mitochondrion (P2ry12) plasma membrane (P2ry12)
signal transducer activity (P2ry12)
Anatomy Link Frequency
spinal 1
neurons 1
P2ry12 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 51 99.12 Very High Very High Very High
Neuropathic pain 3 99.08 Very High Very High Very High
antagonist 21 97.68 Very High Very High Very High
agonist 54 97.04 Very High Very High Very High
imagery 27 95.04 Very High Very High Very High
Pain 6 87.16 High High
Eae 9 85.68 High High
Lasting pain 9 78.88 Quite High
Inflammation 48 70.40 Quite High
Action potential 6 59.64 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 6 99.08 Very High Very High Very High
Nervous System Injury 3 95.92 Very High Very High Very High
Nociception 93 94.44 High High
Pain 15 87.16 High High
Injury 21 70.68 Quite High
INFLAMMATION 48 70.40 Quite High
Inflammatory Pain 6 50.00 Quite Low
Hyperalgesia 48 5.00 Very Low Very Low Very Low
Bordatella Infection 9 5.00 Very Low Very Low Very Low
Overdose 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although P2Y12 immunoreactivity was restricted to small neurons, both P2Y13 and P2Y14 were detected in some larger neurons.
Positive_regulation (restricted) of P2Y12 in neurons
1) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.14 Pain Relevance 0.22
Both P2Y12 and P2Y13 are activated by ADP [16], but, P2Y13 is the only P2Y receptor with high affinity for IDP.
Positive_regulation (activated) of P2Y12
2) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0 Pain Relevance 0.33
Furthermore, there is evidence that P2Y12 is required for the expression of neuropathic pain due to a key role in the activation of spinal microglia after nerve injury [29,30].
Positive_regulation (required) of P2Y12 in spinal associated with nervous system injury and neuropathic pain
3) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.75 Pain Relevance 0.47

General Comments

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