INT308877

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Context Info
Confidence 0.68
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.89
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry13) endoplasmic reticulum (P2ry13) plasma membrane (P2ry13)
signal transducer activity (P2ry13)
Anatomy Link Frequency
dorsal root ganglia 2
sensory neurons 1
neurons 1
P2ry13 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 90 100.00 Very High Very High Very High
intrathecal 5 99.30 Very High Very High Very High
Pain 10 97.56 Very High Very High Very High
MU agonist 10 97.20 Very High Very High Very High
nociceptor 85 96.68 Very High Very High Very High
antagonist 35 94.76 High High
Inflammation 80 94.40 High High
imagery 45 93.84 High High
tail-flick 5 92.88 High High
mu opioid receptor 15 90.56 High High
Disease Link Frequency Relevance Heat
Nociception 155 97.76 Very High Very High Very High
Pain 25 97.56 Very High Very High Very High
INFLAMMATION 80 94.40 High High
Injury 35 93.36 High High
Neuropathic Pain 10 78.40 Quite High
Nervous System Injury 5 72.08 Quite High
Inflammatory Pain 10 50.00 Quite Low
Hyperalgesia 80 45.68 Quite Low
Bordatella Infection 15 5.00 Very Low Very Low Very Low
Overdose 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is possible that extensive co-expression of P2Y12 with P2Y13 in sensory neurons, both of which are Gi/o-coupled ADP receptors, prevents pro-nociceptive consequences of peripheral P2Y12 antagonism in experimental models and in patients using clopidogrel.
Gene_expression (expression) of P2Y13 in sensory neurons associated with nociception
1) Confidence 0.68 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.61 Pain Relevance 0.35
Although P2Y12 immunoreactivity was restricted to small neurons, both P2Y13 and P2Y14 were detected in some larger neurons.
Gene_expression (detected) of P2Y13 in neurons
2) Confidence 0.68 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.14 Pain Relevance 0.22
Intriguingly, these authors also demonstrated that intrathecal administration of a non-selective agonist of P2Y1, P2Y12 and P2Y13 (ADP-?
Gene_expression (agonist) of P2Y13 associated with agonist and intrathecal
3) Confidence 0.59 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.35 Pain Relevance 0.50
Here, we demonstrate that P2Y12, P2Y13 and P2Y14 are all expressed in sensory neurons of the dorsal root ganglia (DRG) with neurochemical characteristics of nociceptors.
Gene_expression (expressed) of P2Y13 in dorsal root ganglia associated with nociceptor
4) Confidence 0.53 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.30 Pain Relevance 0.45
Expression of mRNA for all three of the Gi-coupled P2Y receptors was identified in mouse lumbar DRG by real-time PCR, with relative levels of expression of P2Y12 ~P2Y14 > P2Y13 (Table 1).
Gene_expression (expression) of P2Y13 in DRG
5) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.49 Pain Relevance 0.47

General Comments

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