INT308894

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.49
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry1) mitochondrion (P2ry1) plasma membrane (P2ry1)
signal transducer activity (P2ry1)
Anatomy Link Frequency
sensory neurons 1
Adp (Mus musculus)
P2ry1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 16 98.16 Very High Very High Very High
nociceptor 17 92.88 High High
MU agonist 2 78.32 Quite High
imagery 9 74.96 Quite High
agonist 18 72.04 Quite High
mu opioid receptor 3 71.68 Quite High
Neurotransmitter 3 66.92 Quite High
Eae 3 50.00 Quite Low
Neuropeptide 2 23.84 Low Low
Action potential 2 22.36 Low Low
Disease Link Frequency Relevance Heat
Injury 7 98.44 Very High Very High Very High
INFLAMMATION 16 98.16 Very High Very High Very High
Nociception 31 70.40 Quite High
Inflammatory Pain 2 50.00 Quite Low
Hyperalgesia 16 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Bordatella Infection 3 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Hypoalagesia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results described here indicate that ADP acts at both the Gq-coupled P2Y1 and the Gi-coupled P2Y12 and P2Y13 receptors in sensory neurons, and suggest that the integration of these antagonistic pathways is an important mechanism for the modulation of nociceptor sensitivity.


ADP Regulation (acts) of Gq-coupled P2Y1 in sensory neurons associated with nociceptor
1) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.49 Pain Relevance 0.53

General Comments

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