INT308952

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0.75
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr18) plasma membrane (Gpr18) signal transducer activity (Gpr18)
Anatomy Link Frequency
microglia 4
Gpr18 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 20 99.92 Very High Very High Very High
Inflammation 32 96.52 Very High Very High Very High
agonist 52 72.44 Quite High
antagonist 36 71.08 Quite High
cannabis 4 55.20 Quite High
Endocannabinoid 16 44.36 Quite Low
Cannabinoid 36 41.48 Quite Low
addiction 4 21.84 Low Low
Nicotine 4 21.44 Low Low
IPN 4 20.12 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 32 96.52 Very High Very High Very High
Aging 4 78.88 Quite High
Neurodegenerative Disease 12 61.44 Quite High
Infection 8 25.00 Low Low
Liver Disease 4 23.64 Low Low
Nicotine Addiction 4 21.84 Low Low
Osteoporosis 4 21.04 Low Low
Obesity 4 20.48 Low Low
Inflammatory Pain 4 20.12 Low Low
Neuropathic Pain 4 19.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The marked potency of NAGly acting on GPR18 to elicit directed migration, proliferation and perhaps other MAPK-dependent phenomena advances our understanding of the lipid-based signaling mechanisms employed by the CNS to actively recruit microglia to sites of interest.
Regulation (acting) of GPR18 in microglia associated with potency
1) Confidence 0.23 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2865488 Disease Relevance 0.38 Pain Relevance 0.20
The marked potency of NAGly acting on GPR18 to elicit directed migration, proliferation and perhaps other MAPK-dependent phenomena advances our understanding of the lipid-based signaling mechanisms employed by the CNS to actively recruit microglia to sites of interest.
Regulation (acting) of GPR18 in microglia associated with potency
2) Confidence 0.23 Published 2010 Journal BMC Neurosci Section Abstract Doc Link PMC2865488 Disease Relevance 0 Pain Relevance 0.12
The marked potency of NAGly acting on GPR18 to elicit directed migration, proliferation and perhaps other MAPK-dependent phenomena advances our understanding of the lipid-based signaling mechanisms employed by the CNS to actively recruit microglia to sites of interest.
Regulation (acting) of NAGly in microglia associated with potency
3) Confidence 0.20 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2865488 Disease Relevance 0.38 Pain Relevance 0.20
The marked potency of NAGly acting on GPR18 to elicit directed migration, proliferation and perhaps other MAPK-dependent phenomena advances our understanding of the lipid-based signaling mechanisms employed by the CNS to actively recruit microglia to sites of interest.
Regulation (acting) of NAGly in microglia associated with potency
4) Confidence 0.20 Published 2010 Journal BMC Neurosci Section Abstract Doc Link PMC2865488 Disease Relevance 0 Pain Relevance 0.12

General Comments

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