INT308956

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Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.05
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr18) plasma membrane (Gpr18) signal transducer activity (Gpr18)
Anatomy Link Frequency
microglia 2
Gpr18 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 27 82.32 Quite High
agonist 39 69.84 Quite High
Cannabinoid 27 33.52 Quite Low
Inflammation 24 5.00 Very Low Very Low Very Low
Potency 15 5.00 Very Low Very Low Very Low
Endocannabinoid 12 5.00 Very Low Very Low Very Low
Cannabinoid receptor 9 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
Multiple sclerosis 6 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bordatella Infection 6 53.80 Quite High
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 9 5.00 Very Low Very Low Very Low
Demyelinating Disease 6 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low
Liver Disease 3 5.00 Very Low Very Low Very Low
Osteoporosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of GPR18 affects directed migration induced by NAGly and Abn-CBD
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of GPR18
1) Confidence 0.59 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2865488 Disease Relevance 0 Pain Relevance 0.04
In addition, immunocytochemical staining revealed GPR18 receptors are expressed in a heterogeneous punctuate pattern throughout BV-2 microglia and HEK293 cells stably transfected with GPR18, including their polymerized lamellipodia [44,45] (Figure 6).
Positive_regulation (transfected) of Gene_expression (transfected) of GPR18 in microglia
2) Confidence 0.43 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2865488 Disease Relevance 0.05 Pain Relevance 0
M NAGly-induced migration was also significantly attenuated in the presence of 1 ?
Positive_regulation (attenuated) of Gene_expression (attenuated) of NAGly
3) Confidence 0.37 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2865488 Disease Relevance 0 Pain Relevance 0.11

General Comments

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