INT308970

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.14
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr18) plasma membrane (Gpr18) signal transducer activity (Gpr18)
Anatomy Link Frequency
microglial cells 1
Abn-CBD (Mus musculus)
Gpr18 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 18 94.08 High High
agonist 26 87.28 High High
Inflammation 16 78.20 Quite High
Antinociceptive 2 77.32 Quite High
antagonist 18 59.12 Quite High
Endocannabinoid 8 51.84 Quite High
Cannabinoid receptor 6 21.28 Low Low
Potency 10 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 16 78.20 Quite High
Targeted Disruption 2 56.84 Quite High
Increased Venous Pressure Under Development 4 46.64 Quite Low
Glioma 2 37.44 Quite Low
Brain Injury 2 32.72 Quite Low
Infection 4 31.44 Quite Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Demyelinating Disease 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Bordatella Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our analyses demonstrate that NAGly and Abn-CBD regulate cellular migration through GPR18, and we propose this GPCR is the unidentified 'Abn-CBD' receptor.
Abn-CBD Regulation (regulate) of GPR18
1) Confidence 0.03 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2865488 Disease Relevance 0.06 Pain Relevance 0.15
Here, using the immortalized primary microglial cell line (BV-2) [28], which have been shown to retain most of the morphological, phenotypical and functional properties described for freshly isolated active microglial cells [13,28], we investigate the hypothesis that NAGly and Abn-CBD regulate microglial migration through GPR18; identifying GPR18 as the unknown 'Abn-CBD' receptor.
Abn-CBD Spec (investigate) Regulation (regulate) of GPR18 in microglial cells
2) Confidence 0.03 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2865488 Disease Relevance 0.08 Pain Relevance 0.26

General Comments

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