INT308980

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.30
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adipoq) extracellular region (Adipoq) endoplasmic reticulum (Adipoq)
Anatomy Link Frequency
fat 2
adipocytes 2
Adipoq (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 101 100.00 Very High Very High Very High
cytokine 18 100.00 Very High Very High Very High
Inflammatory response 15 95.24 Very High Very High Very High
Inflammatory mediators 6 68.44 Quite High
tolerance 13 29.44 Quite Low
agonist 16 24.52 Low Low
Tetrahydrobiopterin 1 9.68 Low Low
metalloproteinase 32 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
qutenza 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 122 100.00 Very High Very High Very High
Obesity 227 99.84 Very High Very High Very High
Insulin Resistance 59 98.38 Very High Very High Very High
Hyperinsulinism 5 89.68 High High
Diabetes Mellitus 108 86.96 High High
Hypoglycemia 29 84.20 Quite High
Congenital Anomalies 5 81.52 Quite High
Hypercholesterolemia 2 79.84 Quite High
Stress 3 40.72 Quite Low
Impaired Glucose Tolerance 9 22.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As insulin resistance in response to obesity and high fat feeding has been demonstrated to arise from increased concentrations of local and circulating pro-inflammatory cytokines [21] and from a reduction of circulating adiponectin concentrations [22], [23], we determined these parameters in control- and IR?
Positive_regulation (increased) of Negative_regulation (reduction) of adiponectin in fat associated with inflammation, obesity, insulin resistance and cytokine
1) Confidence 0.33 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.94 Pain Relevance 0.17
In addition, the increases in adiponectin and decrease in high-sensitivity CRP were significantly improved with alogliptin 25 mg + pioglitazone 30 mg versus alogliptin 25 mg/day monotherapy145 (Table 1).


Positive_regulation (increases) of Negative_regulation (decrease) of adiponectin
2) Confidence 0.13 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941781 Disease Relevance 0.38 Pain Relevance 0
-mediated suppression of adiponectin in adipocytes; however, the mechanisms of their inhibitory effects are different; 6-gingerol inhibits JNK signaling pathways in TNF-?
Positive_regulation (mediated) of Negative_regulation (suppression) of adiponectin in adipocytes associated with obesity
3) Confidence 0.07 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2876247 Disease Relevance 0.97 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox