INT309000

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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.03
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1, Mmp9) extracellular region (Ins1, Mmp9) peptidase activity (Mmp9)
proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9) carbohydrate metabolic process (Ins1)
Anatomy Link Frequency
macrophages 2
Ins1 (Mus musculus)
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 32 100.00 Very High Very High Very High
Inflammation 34 50.00 Quite Low
Inflammatory response 3 12.76 Low Low
cytokine 11 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
tramadol 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 15 99.70 Very High Very High Very High
Obesity 126 94.96 High High
Atherosclerosis 4 79.48 Quite High
Stress 2 76.40 Quite High
INFLAMMATION 38 50.00 Quite Low
Cardiovascular Disease 1 45.36 Quite Low
Insulin Resistance 34 42.92 Quite Low
Diabetes Mellitus 6 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Hyperinsulinism 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aside from regulation of macrophage apoptosis, we find that insulin promotes expression and activation of MMP-9 in these cells, a protease involved in tissue invasion by macrophages [25].
insulin Positive_regulation (promotes) of in macrophages Gene_expression (expression) of MMP-9 in macrophage associated with metalloproteinase and apoptosis
1) Confidence 0.20 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.03 Pain Relevance 0.22

General Comments

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