INT309001

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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.96
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1, Mmp9) extracellular region (Ins1, Mmp9) peptidase activity (Mmp9)
proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9) carbohydrate metabolic process (Ins1)
Anatomy Link Frequency
macrophages 1
monocytes 1
Ins1 (Mus musculus)
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 64 100.00 Very High Very High Very High
Inflammation 68 95.84 Very High Very High Very High
cytokine 22 5.00 Very Low Very Low Very Low
tolerance 12 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
tramadol 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cardiovascular Disease 2 97.20 Very High Very High Very High
INFLAMMATION 76 95.84 Very High Very High Very High
Apoptosis 30 83.12 Quite High
Atherosclerosis 8 82.72 Quite High
Obesity 252 78.68 Quite High
Hyperinsulinism 8 67.52 Quite High
Disease 2 65.52 Quite High
Stress 4 60.12 Quite High
Insulin Resistance 68 59.60 Quite High
Diabetes Mellitus 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, San José et al. have recently demonstrated that insulin activates MMP-9 in murine macrophages in a PI3K/PKC-dependent manner through stimulation of the NADPH oxidase system [52].
insulin Positive_regulation (activates) of MMP-9 in macrophages associated with metalloproteinase
1) Confidence 0.20 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.04 Pain Relevance 0.46
Consistent with these results, it has been demonstrated that insulin augments MMP-9 in human monocytes in vitro [50] and that degradation of extracellular matrix (ECM) components by MMP-9 represents a key step during macrophage tissue invasion [51].
insulin Positive_regulation (augments) of MMP-9 in monocytes associated with metalloproteinase
2) Confidence 0.17 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.92 Pain Relevance 0.37

General Comments

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