INT309062

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.43
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpc1, Trpc6) protein complex (Trpc1) transmembrane transport (Trpc1)
cytoplasm (Trpc1)
Anatomy Link Frequency
neuronal 1
adult brain 1
Trpc1 (Rattus norvegicus)
Trpc6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
TRP channel 82 96.04 Very High Very High Very High
Potency 2 12.56 Low Low
imagery 10 5.00 Very Low Very Low Very Low
Calcium channel 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 14 82.20 Quite High
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Otherwise the presence or absence of TRPC5 and TRPC6 in association with TRPC1 may help to explain bFGF-activated current changes during the neuronal differentiation from A2B5+ NPCs possibly via formation of different heteromeric TRPC complexes such as heteromeric TRPC (1+5) and TRPC (1+3+5) channels as described previously [10].
TRPC1 Binding (association) of TRPC6 in neuronal associated with trp channel
1) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0.20 Pain Relevance 0.32
TRPC3 and TRPC6 can form a heteromeric channel complex with TRPC1, TRPC4 and TRPC5 in rat embryonic brain, but not in adult brain [10].
TRPC1 Binding (complex) of TRPC6 in adult brain
2) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0.23 Pain Relevance 0.28

General Comments

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