INT309094

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.07
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gsdmc) cytoplasm (Gsdmc)
Anatomy Link Frequency
brain 1
nucleus 1
Gsdmc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 268 96.16 Very High Very High Very High
Hippocampus 56 93.60 High High
bDMF 96 91.12 High High
agonist 8 90.16 High High
cerebral cortex 4 78.68 Quite High
antagonist 32 78.04 Quite High
anesthesia 16 5.00 Very Low Very Low Very Low
Pyramidal cell 4 5.00 Very Low Very Low Very Low
halothane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 236 96.16 Very High Very High Very High
Cognitive Disorder 64 93.64 High High
Targeted Disruption 36 93.40 High High
Cv Unclassified Under Development 24 88.88 High High
Brain Hemorrhage 8 79.96 Quite High
Death 24 78.60 Quite High
Apoptosis 20 77.16 Quite High
Middle Cerebral Artery Infarction 12 70.52 Quite High
Stroke 24 21.36 Low Low
Endometriosis (extended) 8 9.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Use of fluorescent-labeled EDC and E2-BSA conjugates confirmed that the conjugates exhibit an extranuclear/membrane localization pattern, and do not enter the nucleus after icv injection.
Localization (localization) of extranuclear in nucleus
1) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.27 Pain Relevance 0.34
As shown in Fig.1A (a), FITC-EDC and FITC-E2-BSA conjugates are heavily localized in the CA1 after icv injection, displaying a punctuate extranuclear/membrane pattern of localization.
Localization (localization) of extranuclear
2) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.64 Pain Relevance 0.33
can be localized to the membrane, either extranuclear ER?
Localization (localized) of extranuclear
3) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.65 Pain Relevance 0.39
In addition to genomic signaling, there is increasing evidence that rapid nongenomic signaling via membrane localized extranuclear ER may also play a role in mediating E2 neuroprotective effects in the brain [23], [24], [25].
Localization (localized) of extranuclear in brain
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.52 Pain Relevance 0.31

General Comments

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