INT309118

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.32
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Akt1) transport (Akt1) mitochondrion (Dlat)
aging (Akt1) enzyme binding (Akt1) carbohydrate metabolic process (Akt1)
Anatomy Link Frequency
hippocampus 2
Dlat (Rattus norvegicus)
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 14 98.12 Very High Very High Very High
ischemia 67 96.76 Very High Very High Very High
bDMF 24 60.40 Quite High
antagonist 8 48.68 Quite Low
agonist 2 18.92 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Pyramidal cell 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 59 96.76 Very High Very High Very High
Death 6 49.24 Quite Low
Apoptosis 5 47.80 Quite Low
Cv Unclassified Under Development 6 41.96 Quite Low
Middle Cerebral Artery Infarction 3 41.16 Quite Low
Targeted Disruption 9 7.68 Low Low
Cognitive Disorder 16 5.00 Very Low Very Low Very Low
Stroke 6 5.00 Very Low Very Low Very Low
Brain Hemorrhage 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, E2-induces ERK activation in the CA1 region after GCI, which is critical for its neuroprotective effects as treatment with a MEK inhibitor blocked E2-induced ERK activation and E2 neuroprotection in the hippocampus [27] Likewise, a role for the prosurvival serine kinase Akt in E2 neuroprotection has been implicated, as E2 rapidly up-regulates Akt activation in cortical neurons in vitro [28], and in the hippocampus CA1 in vivo following GCI [29], while treatment with a PI3K inhibitor attenuates the neuroprotective effects of E2 both in vitro and in vivo [28], [29].
E2 Positive_regulation (regulates) of Positive_regulation (activation) of Akt in hippocampus associated with ischemia and hippocampus
1) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.32 Pain Relevance 0.34

General Comments

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