INT309121

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.76
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Gsdmc, Ephb1) endosome (Ephb1) signal transduction (Ephb1)
mitochondrion (Gsdmc) plasma membrane (Ephb1)
Anatomy Link Frequency
neuronal 3
Gsdmc (Rattus norvegicus)
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 67 94.96 High High
antagonist 8 76.28 Quite High
Hippocampus 14 34.64 Quite Low
bDMF 24 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Pyramidal cell 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 1 95.92 Very High Very High Very High
Cognitive Disorder 16 95.08 Very High Very High Very High
Cv General 4 Under Development 59 94.96 High High
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 6 5.00 Very Low Very Low Very Low
Stroke 6 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Middle Cerebral Artery Infarction 3 5.00 Very Low Very Low Very Low
Brain Hemorrhage 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the current study demonstrates that activation of extranuclear ER results in induction of ERK-Akt-CREB-BDNF signaling in the hippocampal CA1 region, which significantly reduces ischemic neuronal injury and preserves cognitive function following GCI.
Positive_regulation (activation) of extranuclear in neuronal Positive_regulation (results) of Positive_regulation (induction) of ERK in neuronal associated with cognitive disorder, ischemia and injury
1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2866326 Disease Relevance 0.76 Pain Relevance 0.28

General Comments

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