INT309122

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.73
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Edc4, Mapk8) cytoplasm (Edc4, Mapk8) cytosol (Mapk8)
signal transduction (Mapk8) mitochondrion (Mapk8) kinase activity (Mapk8)
Edc4 (Rattus norvegicus)
Mapk8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 67 95.00 High High
bDMF 24 92.40 High High
Hippocampus 14 73.12 Quite High
antagonist 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Pyramidal cell 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 59 95.00 High High
Cognitive Disorder 16 94.44 High High
Apoptosis 5 86.16 High High
Death 6 75.44 Quite High
Targeted Disruption 9 66.00 Quite High
Cv Unclassified Under Development 6 5.00 Very Low Very Low Very Low
Stroke 6 5.00 Very Low Very Low Very Low
Middle Cerebral Artery Infarction 3 5.00 Very Low Very Low Very Low
Brain Hemorrhage 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to enhancing activation of the well-known pro-survival factors, ERK, Akt and CREB, our study demonstrated that EDC exerted a prolonged attenuation of phosphorylation of JNK at Thr183/Tyr185, phosphorylation sites known to be critical for JNK activation [61].
EDC Positive_regulation (exerted) of Phosphorylation (phosphorylation) of JNK
1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.73 Pain Relevance 0.28

General Comments

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