INT309123

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.51
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Edc4, Car1) lyase activity (Car1) Golgi apparatus (Car1)
nucleus (Edc4)
Anatomy Link Frequency
hippocampus 1
Edc4 (Rattus norvegicus)
Car1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 48 96.20 Very High Very High Very High
Hippocampus 28 90.00 High High
ischemia 134 89.12 High High
antagonist 16 57.64 Quite High
anesthesia 8 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Pyramidal cell 2 5.00 Very Low Very Low Very Low
halothane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 118 89.12 High High
Cognitive Disorder 32 57.84 Quite High
Apoptosis 10 32.60 Quite Low
Targeted Disruption 18 5.00 Very Low Very Low Very Low
Death 12 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 12 5.00 Very Low Very Low Very Low
Stroke 12 5.00 Very Low Very Low Very Low
Middle Cerebral Artery Infarction 6 5.00 Very Low Very Low Very Low
Brain Hemorrhage 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Fig 7B&C, administration of the PI3K or MEK inhibitor markedly attenuated EDC-induced pCREB elevation in the CA1 region at 10min and 6h after reperfusion, as well as significantly attenuated the EDC-induced BDNF elevation at 6h after reperfusion, suggesting that PI3K-Akt and MEK-ERK signaling pathways mediate the EDC-induced elevation of pCREB and BDNF in the hippocampus following GCI.


EDC Positive_regulation (elevation) of CA1 in hippocampus associated with ischemia, hippocampus and bdmf
1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.39 Pain Relevance 0.52
We also found that a second transcriptional target of CREB, Bcl-2, a potent antiapoptotic factor, was also induced by EDC in the hippocampal CA1 region following ischemic reperfusion (unpublished observation).
EDC Positive_regulation (induced) of CA1
2) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.12 Pain Relevance 0.14

General Comments

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