INT309126

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.99
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Edc4, Akt1) nucleus (Edc4, Akt1) nucleoplasm (Akt1)
transport (Akt1) aging (Akt1) enzyme binding (Akt1)
Anatomy Link Frequency
neurons 1
hippocampus 1
Edc4 (Rattus norvegicus)
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 28 98.56 Very High Very High Very High
ischemia 134 98.44 Very High Very High Very High
bDMF 48 94.56 High High
antagonist 16 34.32 Quite Low
anesthesia 8 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Pyramidal cell 2 5.00 Very Low Very Low Very Low
halothane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 118 98.44 Very High Very High Very High
Death 12 91.60 High High
Cognitive Disorder 32 89.36 High High
Stroke 12 7.84 Low Low
Targeted Disruption 18 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 12 5.00 Very Low Very Low Very Low
Apoptosis 10 5.00 Very Low Very Low Very Low
Middle Cerebral Artery Infarction 6 5.00 Very Low Very Low Very Low
Brain Hemorrhage 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Note also the p-Akt induction is colocalized with NeuN, suggesting that the elevation of p-Akt by EDC and E2-BSA occurs in neurons in the hippocampal CA1 region.


EDC Positive_regulation (elevation) of p-Akt in neurons
1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.45 Pain Relevance 0.19
The results of our study reveal that EDC and E2-BSA administered intracerebroventrically (icv) rapidly activates ERK, Akt and CREB signaling pathways in the hippocampus, enhances levels of the CREB transcriptional target, brain-derived neurotrophic factor (BDNF), strongly protects the hippocampal CA1 region against neuronal cell death, and significantly improves hippocampal-dependent cognitive function in the Morris water maze following GCI.
EDC Positive_regulation (activates) of Akt in hippocampus associated with cognitive disorder, ischemia, hippocampus, bdmf and death
2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.54 Pain Relevance 0.27

General Comments

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