INT309134

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.54
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Edc4, Ephb1) endosome (Ephb1) signal transduction (Ephb1)
plasma membrane (Ephb1) nucleus (Edc4)
Anatomy Link Frequency
hippocampus 1
Edc4 (Rattus norvegicus)
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 67 98.44 Very High Very High Very High
Hippocampus 14 98.36 Very High Very High Very High
bDMF 24 94.36 High High
antagonist 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Pyramidal cell 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 59 98.44 Very High Very High Very High
Death 6 91.40 High High
Cognitive Disorder 16 89.16 High High
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 6 5.00 Very Low Very Low Very Low
Stroke 6 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Middle Cerebral Artery Infarction 3 5.00 Very Low Very Low Very Low
Brain Hemorrhage 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of our study reveal that EDC and E2-BSA administered intracerebroventrically (icv) rapidly activates ERK, Akt and CREB signaling pathways in the hippocampus, enhances levels of the CREB transcriptional target, brain-derived neurotrophic factor (BDNF), strongly protects the hippocampal CA1 region against neuronal cell death, and significantly improves hippocampal-dependent cognitive function in the Morris water maze following GCI.
EDC Positive_regulation (activates) of ERK in hippocampus associated with cognitive disorder, ischemia, hippocampus, bdmf and death
1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.54 Pain Relevance 0.27

General Comments

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