INT309140

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.10
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Dlat, Creb1) nucleoplasm (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) transferase activity, transferring acyl groups (Dlat)
Anatomy Link Frequency
hippocampus 2
Dlat (Rattus norvegicus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 42 98.92 Very High Very High Very High
ischemia 201 98.64 Very High Very High Very High
bDMF 72 94.92 High High
antagonist 24 78.36 Quite High
anesthesia 12 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
Pyramidal cell 3 5.00 Very Low Very Low Very Low
halothane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 177 98.64 Very High Very High Very High
Death 18 91.96 High High
Cognitive Disorder 48 89.72 High High
Apoptosis 15 16.92 Low Low
Targeted Disruption 27 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 18 5.00 Very Low Very Low Very Low
Stroke 18 5.00 Very Low Very Low Very Low
Middle Cerebral Artery Infarction 9 5.00 Very Low Very Low Very Low
Brain Hemorrhage 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It should be noted that Etgen and coworkers [59] previously demonstrated that E2 rapidly elevates pCREB in the hippocampal CA1 following GCI, while Raval et al [60] found that higher serum E2 levels on proestrus was correlated with enhanced pCREB in the hippocampus and increased neuroprotection from GCI, further supporting a potentially critical role for CREB in E2 neural actions.
E2 Positive_regulation (elevates) of pCREB in hippocampus associated with ischemia and hippocampus
1) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.19 Pain Relevance 0.21
E2-BSA also increased pCREB levels similar to EDC at 10min post-reperfusion.
E2 Positive_regulation (increased) of pCREB
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.37 Pain Relevance 0.42
The results of our study reveal that EDC and E2-BSA administered intracerebroventrically (icv) rapidly activates ERK, Akt and CREB signaling pathways in the hippocampus, enhances levels of the CREB transcriptional target, brain-derived neurotrophic factor (BDNF), strongly protects the hippocampal CA1 region against neuronal cell death, and significantly improves hippocampal-dependent cognitive function in the Morris water maze following GCI.
E2 Positive_regulation (activates) of CREB in hippocampus associated with cognitive disorder, ischemia, hippocampus, bdmf and death
3) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.54 Pain Relevance 0.28

General Comments

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