INT309145

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.35
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Edc4, Creb1) nucleoplasm (Creb1) mitochondrion (Creb1)
nucleolus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Edc4 (Rattus norvegicus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 24 98.20 Very High Very High Very High
ischemia 67 89.08 High High
antagonist 8 74.88 Quite High
Hippocampus 14 46.16 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Pyramidal cell 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 59 89.08 High High
Cognitive Disorder 16 24.00 Low Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 6 5.00 Very Low Very Low Very Low
Stroke 6 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Middle Cerebral Artery Infarction 3 5.00 Very Low Very Low Very Low
Brain Hemorrhage 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The early elevation of pCREB levels by EDC, was followed by elevation of its transcriptional target, BDNF at latter time points (6h and 1d reperfusion) in the hippocampal CA1 region.
Positive_regulation (followed) of EDC Positive_regulation (elevation) of pCREB associated with bdmf
1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.35 Pain Relevance 0.42

General Comments

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